PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23600690-1	2013	REASONS FOR PERFORMING STUDY: Metformin is a potential therapeutic agent for the treatment of insulin resistance (IR).	Metformin	30-39	INS	Equus caballus	94-101	
23600690-3	2013	OBJECTIVES: To determine whether pretreatment with metformin reduces plasma glucose concentration and insulin responses following consumption of dextrose in horses.	Metformin	51-60	INS	Equus caballus	102-109	
23600690-9	2013	RESULTS: In healthy horses, the administration of metformin resulted in a statistically significant reduction in peak glucose concentration (P = 0.002), area under the glucose curve (P<0.001) and insulin concentration 120 min after dextrose administration (P = 0.011).	Metformin	50-59	INS	Equus caballus	199-206	
23600690-10	2013	Following the induction of IR, administration of metformin was associated with significant differences in peak glucose concentration (P<0.001), the percentage increase in glucose concentration (P = 0.010), the area under the glucose curve (P<0.001) and insulin concentration at 120 min (P = 0.034) and 150 min after dextrose administration (P = 0.014).	Metformin	49-58	INS	Equus caballus	259-266	
16930507-6	2006	Experiment 2 was designed to investigate the effects of administration of the insulin-sensitising drug metformin hydrochloride on insulin sensitivity and the characteristics of the oestrous cycle in obese mares.	Metformin	103-126	INS	Equus caballus	78-85	
20919907-9	2010	CONCLUSIONS AND CLINICAL RELEVANCE: Metformin reportedly enhances insulin sensitivity of peripheral tissues without stimulating insulin secretion, but bioavailability in horses is low.	Metformin	36-45	INS	Equus caballus	66-73	
16930507-6	2006	Experiment 2 was designed to investigate the effects of administration of the insulin-sensitising drug metformin hydrochloride on insulin sensitivity and the characteristics of the oestrous cycle in obese mares.	Metformin	103-126	INS	Equus caballus	130-137	
16930507-0	2006	Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity.	Metformin	95-104	INS	Equus caballus	108-115	
16930507-7	2006	In a dose-response trial, metformin increased insulin sensitivity after 30 days following administration of 3 g day(-1), but not 6 or 9 g day(-1), compared with controls receiving vehicle only.	Metformin	26-35	INS	Equus caballus	46-53