PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29374065-0	2018	Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer.	Metformin	0-9	5'-nucleotidase ecto	Homo sapiens	40-44	
29374065-2	2018	We show here that metformin treatment blocks the suppressive function of myeloid-derived suppressor cells (MDSC) in patients with ovarian cancer by downregulating the expression and ectoenzymatic activity of CD39 and CD73 on monocytic and polymononuclear MDSC subsets.	Metformin	18-27	5'-nucleotidase ecto	Homo sapiens	217-221	
29374065-3	2018	Metformin triggered activation of AMP-activated protein kinase alpha and subsequently suppressed hypoxia-inducible factor alpha, which was critical for induction of CD39/CD73 expression in MDSC.	Metformin	0-9	5'-nucleotidase ecto	Homo sapiens	170-174	
29374065-4	2018	Furthermore, metformin treatment correlated with longer overall survival in diabetic patients with ovarian cancer, which was accompanied by a metformin-induced reduction in the frequency of circulating CD39+CD73+ MDSC and a concomitant increase in the antitumor activities of circulating CD8+ T cells.	Metformin	13-22	5'-nucleotidase ecto	Homo sapiens	207-211	
29374065-4	2018	Furthermore, metformin treatment correlated with longer overall survival in diabetic patients with ovarian cancer, which was accompanied by a metformin-induced reduction in the frequency of circulating CD39+CD73+ MDSC and a concomitant increase in the antitumor activities of circulating CD8+ T cells.	Metformin	142-151	5'-nucleotidase ecto	Homo sapiens	207-211	
29374065-5	2018	Our results highlight a direct effect of metformin on MDSC and suggest that metformin may yield clinical benefit through improvement of antitumor T-cell immunity by dampening CD39/CD73-dependent MDSC immunosuppression in ovarian cancer patients.Significance: The antitumor activity of an antidiabetes drug is attributable to reduced immunosuppressive activity of myeloid-derived tumor suppressor cells.	Metformin	76-85	5'-nucleotidase ecto	Homo sapiens	180-184	
33747526-11	2021	Regulation of the CD39/CD73/adenosine pathway using metformin may represent a therapeutic option to reverse HBV-induced immune pathogenesis.	Metformin	52-61	5'-nucleotidase ecto	Homo sapiens	23-27