PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35405526-11	2022	The results indicated that metformin decreased the protein levels of GOLPH3, LDHA, HK2, MCT-4 and improved p-AMPK expression.	Metformin	27-36	hexokinase 2	Homo sapiens	83-86	
35460908-2	2022	Metformin (Met) is a promising drug for tumor treatment that targets hexokinase 2 (HK2) to block the glycolytic process, thereby further disrupting the metabolism of cancer cells.	Metformin	0-9	hexokinase 2	Homo sapiens	69-81	
35460908-2	2022	Metformin (Met) is a promising drug for tumor treatment that targets hexokinase 2 (HK2) to block the glycolytic process, thereby further disrupting the metabolism of cancer cells.	Metformin	0-9	hexokinase 2	Homo sapiens	83-86	
32083006-0	2020	Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma.	Metformin	48-57	hexokinase 2	Homo sapiens	0-12	
30745857-5	2019	Using endometrial tissues from PCOS patients with hyperplasia, we found that in response to metformin treatment in vitro, hexokinase 2 (HK2) expression was decreased, whereas phosphofructokinase (PFK), PKM2, and lactate dehydrogenase A (LDHA) expression was increased compared to controls.	Metformin	92-101	hexokinase 2	Homo sapiens	122-134	
31486135-10	2019	Finally, we demonstrated that the clinically approved drug metformin sensitizes chemoresistant OVCA cells to CDDP via PDK1-HKII pathway.	Metformin	59-68	hexokinase 2	Homo sapiens	123-127	
30745857-5	2019	Using endometrial tissues from PCOS patients with hyperplasia, we found that in response to metformin treatment in vitro, hexokinase 2 (HK2) expression was decreased, whereas phosphofructokinase (PFK), PKM2, and lactate dehydrogenase A (LDHA) expression was increased compared to controls.	Metformin	92-101	hexokinase 2	Homo sapiens	136-139	
29285270-0	2017	Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells.	Metformin	0-9	hexokinase 2	Homo sapiens	78-90	
29946147-0	2018	Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.	Metformin	146-155	hexokinase 2	Homo sapiens	19-31	
29386513-0	2018	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.	Metformin	127-136	hexokinase 2	Homo sapiens	0-12	
29285270-5	2017	We attempted to investigate the effects of the antidiabetic drug metformin on HK2 expression and lung cancer chemoprevention.	Metformin	65-74	hexokinase 2	Homo sapiens	78-81	
25790097-7	2015	Metformin inhibited HK2, GLUT1, HIF-1alpha expression and glucose consumption.	Metformin	0-9	hexokinase 2	Homo sapiens	20-23	
29285270-6	2017	Our results showed that metformin decreases nickel-induced autophagy and activation of apoptosis through inhibition of HK2 gene, protein and activity.	Metformin	24-33	hexokinase 2	Homo sapiens	119-122	
29285270-12	2017	Taken together, our results demonstrated that metformin alleviates NiCl2-induced autophagy and apoptosis via HK2-driven LCN2 activation in human bronchial epithelial cells.	Metformin	46-55	hexokinase 2	Homo sapiens	109-112	
27920093-8	2017	18F-FDG uptake reduced after metformin treatment in a dose-dependent manner, corresponding to the reduced expression level of HK2 and GLUT1 in vitro Xenograft model of PTC using BCPAP cells was achieved successfully.	Metformin	29-38	hexokinase 2	Homo sapiens	126-129	
27920093-10	2017	Immunohistochemistry staining further confirmed the reduction of HK2 and GLUT1 expression in the tumor tissue of metformin-treated PTC xenograft model.	Metformin	113-122	hexokinase 2	Homo sapiens	65-68	
28498475-2	2017	We suppressed HK2 expression and/or function by shRNA and/or metformin and found HK2 inhibition enhanced cells apoptosis with accelerating expression of cleaved PARP and caspase-3.	Metformin	61-70	hexokinase 2	Homo sapiens	14-17