PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21391472-4 2011 The aim of the study was to assess whether sex hormone binding globulin (SHBG) (a surrogate marker of insulin resistance) could predict a positive response to metformin treatment in women with PCOS. Metformin 159-168 sex hormone binding globulin Homo sapiens 43-71 21194687-2 2011 The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics. Metformin 11-20 sex hormone binding globulin Homo sapiens 105-133 21391472-4 2011 The aim of the study was to assess whether sex hormone binding globulin (SHBG) (a surrogate marker of insulin resistance) could predict a positive response to metformin treatment in women with PCOS. Metformin 159-168 sex hormone binding globulin Homo sapiens 73-77 21391472-8 2011 In this group, patients who responded to metformin treatment had significantly lower SHBG levels compared to those who did not (median SHBG 37.5 nmol/L compared to 56.0 nmol/L) (p = 0.016, Mann-Whitney U-test). Metformin 41-50 sex hormone binding globulin Homo sapiens 85-89 21391472-8 2011 In this group, patients who responded to metformin treatment had significantly lower SHBG levels compared to those who did not (median SHBG 37.5 nmol/L compared to 56.0 nmol/L) (p = 0.016, Mann-Whitney U-test). Metformin 41-50 sex hormone binding globulin Homo sapiens 135-139 21391472-10 2011 CONCLUSIONS: Patients with a positive response to metformin treatment had significantly lower pre-treatment SHBG levels. Metformin 50-59 sex hormone binding globulin Homo sapiens 108-112 21391472-11 2011 For every unit increase in SHBG, the odds of a patient having a positive outcome to metformin treatment fell by a factor of 0.983. Metformin 84-93 sex hormone binding globulin Homo sapiens 27-31 20023292-6 2010 RESULTS: (i) In newborns, SHBG levels were higher in the metformin group. Metformin 57-66 sex hormone binding globulin Homo sapiens 26-30 20596715-8 2010 CONCLUSION: The results of this study show that 2,500 mg daily dose of metformin in obese patients with PCOS is effective in the reduction of BMI, waist hip/ratio, LDL, serum insulin and increases SHBG. Metformin 71-80 sex hormone binding globulin Homo sapiens 197-201 20691435-2 2010 Longer SHBG (TAAAA)(n) alleles (>8 repeats) were associated with more improvement of the lipid profile after 1 year on metformin, whereas longer AR (CAG)(n) alleles were related to more normalization of the androgen and lipid levels after therapy; longer alleles in both genes had an additive effect on the beneficial changes of SHBG, T, and lipids after metformin. Metformin 122-131 sex hormone binding globulin Homo sapiens 7-11 19998243-10 2010 CONCLUSIONS: Long-term treatment with metformin in women with PCOS appears to reduce androgen excess due to increased SHBG and decreased TT levels resulting in improvement of hirsutism as a clinical sign of androgen excess. Metformin 38-47 sex hormone binding globulin Homo sapiens 118-122 20023292-11 2010 CONCLUSIONS: Intrauterine metformin exposure seems to result in elevated SHBG levels in newborns. Metformin 26-35 sex hormone binding globulin Homo sapiens 73-77 16116971-6 2005 Combined use of CPA and metformin could result in the reduction of serum androstenedione and increases of serum SHBG levels as compared with the CPA treatment alone. Metformin 24-33 sex hormone binding globulin Homo sapiens 112-116 17666089-9 2007 RESULTS: After 6 months of metformin therapy, women with PCOS had decreased LH, total testosterone, free androgen index and slightly increased SHBG levels. Metformin 27-36 sex hormone binding globulin Homo sapiens 143-147 19178532-0 2009 The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis. Metformin 15-24 sex hormone binding globulin Homo sapiens 53-57 19178532-15 2009 CONCLUSIONS: Our systematic review and meta-analysis provides evidence of metformin-induced changes in circulating androgens and SHBG levels in women but the quality of evidence is not high. Metformin 74-83 sex hormone binding globulin Homo sapiens 129-133 17505944-5 2007 This implies that, by improving insulin and carbohydrate metabolism, metformin administration in PCOS patients could indirectly contribute to increase SHBG concentration. Metformin 69-78 sex hormone binding globulin Homo sapiens 151-155 17426408-13 2007 Metformin also helps to increase SHBG, decrease androgen levels and induce ovulation. Metformin 0-9 sex hormone binding globulin Homo sapiens 33-37 16492692-9 2006 Metformin was also associated with lower insulin resistance and leptin and IGF-I levels and higher SHBG and IGF-binding protein-1 levels and with a more favorable lipid profile. Metformin 0-9 sex hormone binding globulin Homo sapiens 99-103 15356029-7 2004 In the prepubertal study (group A), comparisons of untreated vs. treated girls disclosed normalizing effects of metformin on SHBG, androstenedione, dehydroepiandrosterone sulfate, low and high density lipoprotein cholesterol, triglycerides, IL-6, adiponectin, total and abdominal fat mass, and lean body mass. Metformin 112-121 sex hormone binding globulin Homo sapiens 125-129 12235466-11 2002 CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. Metformin 12-21 sex hormone binding globulin Homo sapiens 157-185 15063962-8 2004 Metformin treatment also significantly decreased testosterone (by 37%, P = 0.0001) and increased SHBG concentration (by 16%, P = 0.04). Metformin 0-9 sex hormone binding globulin Homo sapiens 97-101 12153743-10 2002 There was a non-significant improvement in both sex hormone binding globulin (SHBG) and free androgen index (FAI), although there was a significant difference between baseline and metformin treatment for SHBG (P=0.023) and FAI (P=0.036). Metformin 180-189 sex hormone binding globulin Homo sapiens 204-208 12093831-8 2002 Adding metformin also caused significant improvements in serum androstenedione and SHBG levels compared with the OC treatment alone. Metformin 7-16 sex hormone binding globulin Homo sapiens 83-87 11937980-6 2002 Although metformin restores cyclic pituitary- gonadal function and improves fertility, it can decrease levels of androgen and LH and increase levels of SHBG in women with PCOS. Metformin 9-18 sex hormone binding globulin Homo sapiens 152-156 11789058-14 2001 The best prediction of the improvement in menstrual cyclicity after metformin was achieved with the combination of basal 17OH progesterone, androstendione, testosterone and SHBG. Metformin 68-77 sex hormone binding globulin Homo sapiens 173-177 11961383-5 2002 The best prediction of the improvement in menstrual cyclicity after metformin was achieved with a combination of basal values of 17-hydroxyprogesterone, testosterone, sex hormone binding globulin, and androstenedione. Metformin 68-77 sex hormone binding globulin Homo sapiens 167-195 35530948-12 2022 Discussion: Although the relative low quality of randomized controlled trials (RCTs) and limited results made it difficult to draw a definite conclusion, our study showed that metformin treatment during pregnancy can reduce the risk of pregnancy complications but may have impacts on increasing SHBG levels and long-term BMI in offspring. Metformin 176-185 sex hormone binding globulin Homo sapiens 295-299 9398716-7 1997 In the metformin group, serum free testosterone decreased by 70% from 18.2 +/- 3.1 to 5.5 +/- 0.7 pmol/L (P < 0.001), and serum sex hormone-binding globulin increased from 84 +/- 6 to 134 +/- 15 nmol/L (P = 0.002). Metformin 7-16 sex hormone binding globulin Homo sapiens 131-159 7608255-0 1995 Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. Metformin 20-29 sex hormone binding globulin Homo sapiens 48-76 10856473-7 2000 RESULT(S): Metformin therapy resulted in a significant decrease in fasting insulin and total T and an increase in SHBG, leading to a decrease in the free T index. Metformin 11-20 sex hormone binding globulin Homo sapiens 114-118 9609021-9 1997 CONCLUSIONS: Metformin has a favorable effect on tissue sensitivity to insulin, SHBG and serum lipids in obese and hyperandrogenic women. Metformin 13-22 sex hormone binding globulin Homo sapiens 80-84 28208875-7 2016 Similarly, SHBG levels were significantly higher in sulfonylurea treated patients compared to metformin treated patients p < 0.0001. Metformin 94-103 sex hormone binding globulin Homo sapiens 11-15 32866967-11 2020 Metformin also reduced A4 (p=0.036), T (p=0.023) and SHBG (p=0.010) levels through pregnancy in mothers with a male foetus. Metformin 0-9 sex hormone binding globulin Homo sapiens 53-57 28698075-1 2017 OBJECTIVE: To evaluate the effects of short- and long-term treatment with metformin and NAC, in an adjuvant to clomiphene citrate (CC), on the improvement of hormonal profile (SHBG, total testosterone, FBS, and fasting insulin) and fertility status in CC-resistant women with PCOS. Metformin 74-83 sex hormone binding globulin Homo sapiens 176-180 33328161-3 2020 The purpose of this analysis was to determine whether intensive lifestyle intervention (ILS) or metformin changed circulating SHBG and if resultant changes influenced diabetes risk in the Diabetes Prevention Program (DPP). Metformin 96-105 sex hormone binding globulin Homo sapiens 126-130 25332100-6 2015 RESULTS: After 24 months, metformin-treated children were leaner, had higher SHBG levels, and less total and abdominal fat than placebo-treated children (all p <= 0.05). Metformin 26-35 sex hormone binding globulin Homo sapiens 77-81 23608322-10 2013 Metformin and weight reduction therapy resulted in a significant decrease in the lipid parameters, testosterone, LH/FSH ratio, SHBG, and prolactin levels. Metformin 0-9 sex hormone binding globulin Homo sapiens 127-131 24319557-7 2013 Patients who responded to metformin treatment had significantly lower mean SHBG levels compared to those who did not (0.88+0.32vs. Metformin 26-35 sex hormone binding globulin Homo sapiens 75-79