PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31489252-9	2019	Of note, we found that metformin treatment of HeLa cells increased the levels of p21 and p27 (which are AMPK-dependent cell cycle inhibitors), leading to increased cell cycle arrest and apoptosis in HeLa cells compared to untreated cells.	Metformin	23-32	interferon alpha inducible protein 27	Homo sapiens	89-92	
27600020-3	2016	Pre-incubation of cells with metformin, an AMPK activator, blocked PDGF-induced activation of mTOR and its downstream targets changes of Skp2 and p27 without changing Akt phosphorylation and inhibited ASMCs proliferation.	Metformin	29-38	interferon alpha inducible protein 27	Homo sapiens	146-149	
27600020-4	2016	Transfection of ASMCs with AMPK alpha2-specific small interfering RNA (siRNA) reversed the effect of metformin on mTOR phosphorylation, Skp2 and p27 protein expression and cell proliferation.	Metformin	101-110	interferon alpha inducible protein 27	Homo sapiens	145-148	
24809794-3	2014	The results of the study further indicated that the proliferation of PASMCs stimulated by ET-1 was associated with the increase of Skp2 and decrease of p27, and metformin reversed ET-1-induced Skp2 elevation and raised p27 protein level.	Metformin	161-170	interferon alpha inducible protein 27	Homo sapiens	219-222	
25955843-6	2015	Moreover, we showed that the down-regulation of miR-221 by metformin caused G1-phase arrest via the up-regulation of p27, one of the direct targets of miR-221.	Metformin	59-68	interferon alpha inducible protein 27	Homo sapiens	117-120	
24858012-8	2014	In MCF-7 cells metformin decreased the activation of IRbeta, Akt and ERK1/2, increased p-AMPK, FOXO3a, p27, Bax and cleaved caspase-3, and decreased phosphorylation of p70S6K and Bcl-2 protein expression.	Metformin	15-24	interferon alpha inducible protein 27	Homo sapiens	103-106	
23974492-6	2013	As a result, protein abundance of p27, p57 and PTEN were increased in cells exposed to metformin.	Metformin	87-96	interferon alpha inducible protein 27	Homo sapiens	34-37	
19440038-7	2009	At the molecular level, metformin increases P-AMPK, reduces P-EGFR, EGFR, P-MAPK, P-Src, cyclin D1 and cyclin E (but not cyclin A or B, p27 or p21), and induces PARP cleavage in a dose- and time-dependent manner.	Metformin	24-33	interferon alpha inducible protein 27	Homo sapiens	136-139	
22593441-15	2012	The analysis of cell cycle-regulating proteins cyclin D, cyclin E and p27 by western blot indicated that the synergistic inhibition of G1 phase of the cell cycle by the combination treatment of metformin, chemotherapeutic drugs and/or RAD001 contributed to the synergistic inhibition of cell proliferation.	Metformin	194-203	interferon alpha inducible protein 27	Homo sapiens	70-73	
22773548-9	2013	Cell line studies showed that metformin inhibits hepatocyte proliferation and induces cell cycle arrest at G0/G1 phase via AMP-activated protein kinase and its upstream kinase LKB1 to upregulate p21/Cip1 and p27/Kip1 and downregulate cyclin D1 in a dose-dependent manner, but independent of p53.	Metformin	30-39	interferon alpha inducible protein 27	Homo sapiens	208-211	
22421144-8	2012	Mechanistically, metformin caused G 1 arrest, which coincided with a decrease in the protein levels of CDKs (2, 4 and 6), cyclins (D1 and E) and CDK inhibitors (p15, p16, p18 and p27), but no change in p19 and p21.	Metformin	17-26	interferon alpha inducible protein 27	Homo sapiens	179-182