PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3770275-3	1986	Soleus muscles of metformin treated mice showed a 41% increase in total insulin receptor number, and a 20% increase in 3-0-methylglucose uptake at both submaximally and maximally stimulating insulin concentrations.	Metformin	18-27	insulin receptor	Mus musculus	72-88	
28407669-10	2017	Furthermore, metformin reduced serum insulin as well as IGF-1, and also suppressed expression of insulin receptor, IGF-1, IGF-1 receptor and several pro-inflammatory cytokines mRNAs in stomach of db/db mice, but did not significantly influence IGF-2 and IGF-2 receptor expressions.	Metformin	13-22	insulin receptor	Mus musculus	97-113	
6354812-1	1983	The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice.	Metformin	14-23	insulin receptor	Mus musculus	38-54	
21102522-2	2011	We treated both tumor LKB1 expression and host diet as variables, and observed that metformin inhibited tumor growth and reduced insulin receptor activation in tumors of mice with diet-induced hyperinsulinemia, independent of tumor LKB1 expression.	Metformin	84-93	insulin receptor	Mus musculus	129-145	
28393204-6	2017	The IR expression level was significantly higher in murine subcutaneous flank tumors of the low-carbohydrate diet group and high-carbohydrate diet plus metformin group than of the high-carbohydrate diet group.	Metformin	152-161	insulin receptor	Mus musculus	4-6	
21811094-4	2011	Metformin abolished the diet-induced increases in serum insulin level, tumor insulin receptor activation and tumor FDG uptake associated with the high energy diet but had no effect on these measurements in mice on a control diet.	Metformin	0-9	insulin receptor	Mus musculus	77-93	
18469156-7	2008	Metformin attenuated the increased insulin receptor activation associated with the high-energy diet and also led to increased phosphorylation of AMP kinase, two actions that would be expected to decrease neoplastic proliferation.	Metformin	0-9	insulin receptor	Mus musculus	35-51