PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20869956-10	2010	Both doses of UA lowered splenic IL-6 levels, whereas metformin increased IFN-gamma, IL-6 and TNF-alpha levels compared to the untreated diabetic mice.	Metformin	54-63	interferon gamma	Mus musculus	74-83	
24770553-4	2015	Metformin + Con A-treated mice had elevated serum levels of pro-inflammatory cytokines TNF-alpha and IFN-gamma, accompanied by a massive mononuclear cell infiltration in the liver.	Metformin	0-9	interferon gamma	Mus musculus	101-110	
25673763-5	2015	In vitro, both the mitochondrial metabolism inhibitor metformin and the glucose metabolism inhibitor 2-deoxy-d-glucose (2DG) reduced interferon-gamma (IFN-gamma) production, although at different stages of activation.	Metformin	54-63	interferon gamma	Mus musculus	133-149	
25673763-5	2015	In vitro, both the mitochondrial metabolism inhibitor metformin and the glucose metabolism inhibitor 2-deoxy-d-glucose (2DG) reduced interferon-gamma (IFN-gamma) production, although at different stages of activation.	Metformin	54-63	interferon gamma	Mus musculus	151-160	
34815353-6	2021	The effect of metformin on IFN-gamma induced PD-L1 expression in tumor cells was assessed by flow cytometry, western blot, and RT-qPCR.	Metformin	14-23	interferon gamma	Mus musculus	27-36	
34664819-7	2021	Treatment of the BC mice with metformin alone and in combination with cimetidine and/or ibuprofen enhanced the frequency of Th1 cells, and IFN-gamma concentration, while it resulted in a decrease in the frequency of Treg cells, serum TGF-beta concentration, and the expression of FOXP3 and TGF-beta compared with un-treated BC mice.	Metformin	30-39	interferon gamma	Mus musculus	139-148	
25370454-7	2015	These observations were further supported by the fact that metformin treatment inhibited CD3/CD28-induced IFN-gamma and IL-17A expression along with the transcription factors that drive their expression (T-bet [Th1] and ROR-gammat [Th17], respectively).	Metformin	59-68	interferon gamma	Mus musculus	106-115	
35334358-12	2022	Inspiringly, we identified that disulfiram and metformin could augment gut Akkermansia abundance, reduce serum IFN-gamma level, inhibit macrophage pyroptosis in ovaries, therefore ameliorating PCOS.	Metformin	47-56	interferon gamma	Mus musculus	111-120	
35064693-0	2022	Metformin ameliorates chronic colitis in a mouse model by regulating interferon-gamma-producing lamina propria CD4+ T cells through AMPK activation.	Metformin	0-9	interferon gamma	Mus musculus	69-85	
35064693-6	2022	We observed that metformin suppresses the frequency of interferon (IFN) -gamma-producing LP CD4+ T cells in vitro, which were regulated by AMPK activation, a process possibly induced by the inhibition of oxidative phosphorylation.	Metformin	17-26	interferon gamma	Mus musculus	55-78	
35064693-9	2022	Our study demonstrates that metformin-induced AMPK activation in mucosal CD4+ T cells contributes to the improvement of IBD by suppressing IFN-gamma production.	Metformin	28-37	interferon gamma	Mus musculus	139-148	
28689771-8	2018	Therapeutic interventions with tacrolimus or metformin normalized the expression of decidual IFNgamma, PGR and FKBP52, increased co-localization of protein inhibitor of activated STATy (PIASy) to PGR and resulted in the upregulation of uterine IL11and LIF.	Metformin	45-54	interferon gamma	Mus musculus	93-101	
28002460-9	2016	In addition, metformin supplementation in IL10KO mice suppressed macrophage pro-inflammatory activity as indicated by reduced M1 macrophage abundance and decreased pro-inflammatory cytokine IL-1beta, TNF-alpha and IFN-gamma expressions.	Metformin	13-22	interferon gamma	Mus musculus	214-223