PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20688914-8 2010 In addition, metformin or overexpression of a constitutively active form of AMPK (Ad-CA-AMPK) inhibited S171A-mediated PEPCK and G6Pase gene expression, and hepatic glucose production and knockdown of SHP partially relieved the metformin- and Ad-CA-AMPK-mediated repression of hepatic gluconeogenic enzyme gene expression in primary rat hepatocytes. Metformin 13-22 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 129-135 26548416-8 2015 By suppressing SRC-2 at the transcriptional level, metformin impeded recruitment of SRC-2 and RNA polymerase II to the G6Pc promoter and to SREs of mutual SRC-2/SREBP-1 target gene promoters. Metformin 51-60 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 119-123 11811898-10 2001 Hepatic glucose-6-phosphatase activity was significantly lower (P<0.05) in AF- and metformin-treated groups, but not in BuF-treated groups, compared to that in vehicle-treated group. Metformin 86-95 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 8-29 20566445-13 2010 Only metformin increased hepatic glycogen, and normalized glucose-6-phosphatase activity. Metformin 5-14 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 58-79 19664596-0 2009 Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. Metformin 0-9 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 21-42 19664596-2 2009 Both metformin and rotenone, an inhibitor of respiratory chain complex I, suppressed glucose-6-phosphatase (G6pc), a rate limiting enzyme of liver glucose production, mRNA expression in a rat hepatoma cell line accompanied by a reduction of intracellular ATP concentration and an activation of AMP-activated protein kinase (AMPK). Metformin 5-14 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 85-106 19664596-2 2009 Both metformin and rotenone, an inhibitor of respiratory chain complex I, suppressed glucose-6-phosphatase (G6pc), a rate limiting enzyme of liver glucose production, mRNA expression in a rat hepatoma cell line accompanied by a reduction of intracellular ATP concentration and an activation of AMP-activated protein kinase (AMPK). Metformin 5-14 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 108-112 19664596-4 2009 Interestingly, in contrast to rotenone treatment, G6pc mRNA down-regulation was observed in the NDI1 expressing cells after metformin treatment. Metformin 124-133 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 50-54 19664596-5 2009 Since NDI1 can functionally complement the complex I under the presence of metformin or rotenone, our results indicate that metformin induces down-regulation of G6pc expression through an inhibition of complex I and an activation of AMPK-independent mechanism. Metformin 124-133 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 161-165 15702236-0 2005 Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells. Metformin 0-9 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 33-54 15702236-2 2005 To elucidate the pharmacological action of metformin on hepatic glucose production, we examined its effect on the gene expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in H4IIE rat hepatoma cell line by RT-PCR and quantitative real-time PCR. Metformin 43-52 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 133-154 15702236-2 2005 To elucidate the pharmacological action of metformin on hepatic glucose production, we examined its effect on the gene expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in H4IIE rat hepatoma cell line by RT-PCR and quantitative real-time PCR. Metformin 43-52 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 156-162 15702236-3 2005 Metformin suppressed dexamethasone/cAMP-induced expression of G6Pase mRNA in a dose dependent manner, its maximum effect being observed at 2 mM (79.3% inhibition, P<0.05). Metformin 0-9 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 62-68 15702236-6 2005 In the present study, we demonstrate that metformin suppresses G6Pase mRNA expression by a mechanism that is independent of the activation of PI3-kinase, Akt, MAP kinase and protein kinase C pathway in hepatocytes. Metformin 42-51 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 63-69 33634460-10 2021 Metformin normalized the alterations in the expression of glucose metabolism-related genes (PGC-1alpha, G6pc, Pepck, Gck, PYGL, Gys2, PKLR, GLUT4) and insulin resistance-related genes (AdipoR1, AdipoR2) in the muscles and livers of rats induced by CORT. Metformin 0-9 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 104-108 11603293-11 2000 The activity of hepatic glucose-6-phosphatase (G-6-Pase) was significantly reduced by the extract as well as by metformin (both P < 0.05). Metformin 112-121 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 24-45 11603293-11 2000 The activity of hepatic glucose-6-phosphatase (G-6-Pase) was significantly reduced by the extract as well as by metformin (both P < 0.05). Metformin 112-121 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 47-55 32423242-7 2020 Also, a significant (P < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, and all anti-inflammatory parameters were observed in diabetic rats administered the extracts and metformin. Metformin 207-216 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 86-107 32092034-7 2020 We observed that dapagliflozin or metformin mitigated the enhanced expression of renal gluconeogenic enzymes, PEPCK, G6Pase and FBPase, as well as improved glucose tolerance and renal function in obese rats. Metformin 34-43 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 117-123