PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32389830-9 2020 The expression of Cx43 shows a significant downregulation(about 38%, P<0.001) after chronic pacing and treating with metformin could alleviate this decrease(P<0.01). Metformin 117-126 gap junction protein alpha 1 Canis lupus familiaris 18-22 32389830-12 2020 These pacing-induced lateralize Cx43 could be alleviated by the metformin (48.4 +- 8.62 vs. 60.8 +- 9.13%, P<0.05). Metformin 64-73 gap junction protein alpha 1 Canis lupus familiaris 32-36 32389830-13 2020 Additionally, metformin could affect the interactions of ZO-1 with p-Src/Cx43 via decrease the abnormal cAMP level after pacing (84.04 +- 4.58 vs. 69.34 +- 4.5 nmol/L, P<0.001). Metformin 14-23 gap junction protein alpha 1 Canis lupus familiaris 73-77