PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15665022-9	2005	CONCLUSION: There was a differential effect of metformin therapy in PCOS women on the basis of IRS genotype.	Metformin	47-56	isoleucyl-tRNA synthetase 1	Homo sapiens	95-98	
12511230-7	2003	In contrast, metformin in pharmacological concentration (1-10 mmol/L) further inhibited tyrosine phosphorylation of IR?, IRS1, IRS2 and the interaction of PI3K with IRS.	Metformin	13-22	isoleucyl-tRNA synthetase 1	Homo sapiens	121-124	
33007330-7	2021	Targeting IRS with IRS1 KO or IRS inhibitor NT157 significantly sensitized FGFR1 overexpressing cells to metformin.	Metformin	105-114	isoleucyl-tRNA synthetase 1	Homo sapiens	10-13	
33007330-7	2021	Targeting IRS with IRS1 KO or IRS inhibitor NT157 significantly sensitized FGFR1 overexpressing cells to metformin.	Metformin	105-114	isoleucyl-tRNA synthetase 1	Homo sapiens	19-22	
32970287-8	2020	In contrast the IRS/PI3-K/AKT pathway signaling components, Akt and GLUT4 increased in insulin-resistant 3T3L1 adipocytes and human diabetic adipose tissue after three months of metformin treatment.	Metformin	178-187	isoleucyl-tRNA synthetase 1	Homo sapiens	16-19	
32970287-9	2020	CONCLUSIONS: Metformin reduced insulin resistance in adipocytes by reduction of miR223 expression and improving of IRS/Akt/GLUT4 signaling pathways.	Metformin	13-22	isoleucyl-tRNA synthetase 1	Homo sapiens	115-118	
15665022-7	2005	RESULTS: Metformin had differential effects on fasting insulin levels, insulin resistance as demonstrated by homeostasis model assessment (HOMA), LH, total testosterone, dehydroepiandrosterone sulphate and free testosterone index on the basis of IRS genotype.	Metformin	9-18	isoleucyl-tRNA synthetase 1	Homo sapiens	246-249