PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33487223-0 2021 Retraction notice to "The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC" [EBioMedicine 37 (2018) 188-204]. Metformin 46-55 Yes1 associated transcriptional regulator Homo sapiens 70-73 34298652-0 2021 Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 59-62 35264157-0 2022 Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling. Metformin 30-39 Yes1 associated transcriptional regulator Homo sapiens 110-114 35264157-12 2022 Further study showed that metformin blocked the cells in G1 phase by inducing phosphorylated YAP1 and reducing the expression of cyclin D1, CDK6, CDK4 and RB, which enhanced the chemosensitivity of cisplatin and activated the expression of cleaved caspase 3 in TGCTs. Metformin 26-35 Yes1 associated transcriptional regulator Homo sapiens 93-97 35264157-13 2022 CONCLUSIONS: Our study discovers the important role of YAP1 in TGCTs and reports a new treatment strategy that employs the sequential administration of metformin and cisplatin, which can reduce the required cisplatin dose and enhance the sensitivity of TGCT cells to cisplatin. Metformin 152-161 Yes1 associated transcriptional regulator Homo sapiens 55-59 33650651-0 2021 Metformin inhibits mTOR and c-Myc by decreasing YAP protein expression in OSCC cells. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 48-51 33650651-2 2021 However, few studies have explored the role of Yes-associated protein (YAP), a vital factor contributing to OSCC biology, in metformin-induced anticancer activity in OSCC cells. Metformin 125-134 Yes1 associated transcriptional regulator Homo sapiens 47-69 33650651-2 2021 However, few studies have explored the role of Yes-associated protein (YAP), a vital factor contributing to OSCC biology, in metformin-induced anticancer activity in OSCC cells. Metformin 125-134 Yes1 associated transcriptional regulator Homo sapiens 71-74 33650651-3 2021 Thus, the purpose of the present study was to investigate the molecular relationship between metformin and YAP in OSCC cells. Metformin 93-102 Yes1 associated transcriptional regulator Homo sapiens 107-110 33650651-8 2021 Alteration of YAP protein expression affected metformin-mediated changes in the cell cycle and apoptosis of CAL27 and SCC25 cells. Metformin 46-55 Yes1 associated transcriptional regulator Homo sapiens 14-17 33650651-9 2021 In addition, compared to the control treatment, metformin treatment decreased the protein levels of YAP, mTOR, p-mTOR and c-Myc. Metformin 48-57 Yes1 associated transcriptional regulator Homo sapiens 100-103 33650651-10 2021 The overexpression of YAP alleviated the inhibitory effect of metformin on the protein expression of mTOR, p-mTOR and c-Myc. Metformin 62-71 Yes1 associated transcriptional regulator Homo sapiens 22-25 33650651-12 2021 Therefore, the results of the present study suggest that metformin suppresses OSCC by inhibiting YAP protein expression and by suppressing the YAP-mediated effects of metformin on the protein expression of mTOR and c-Myc. Metformin 57-66 Yes1 associated transcriptional regulator Homo sapiens 97-100 33650651-12 2021 Therefore, the results of the present study suggest that metformin suppresses OSCC by inhibiting YAP protein expression and by suppressing the YAP-mediated effects of metformin on the protein expression of mTOR and c-Myc. Metformin 57-66 Yes1 associated transcriptional regulator Homo sapiens 143-146 33650651-12 2021 Therefore, the results of the present study suggest that metformin suppresses OSCC by inhibiting YAP protein expression and by suppressing the YAP-mediated effects of metformin on the protein expression of mTOR and c-Myc. Metformin 167-176 Yes1 associated transcriptional regulator Homo sapiens 143-146 33487223-0 2021 Retraction notice to "The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC" [EBioMedicine 37 (2018) 188-204]. Metformin 46-55 Yes1 associated transcriptional regulator Homo sapiens 115-118 31906986-0 2020 Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 28-31 32281270-3 2020 Metformin (MET), a first-line diabetes medication that also has anti-tumour activities, induces AMP-activated protein kinase (AMPK), directly phosphorylates YAP and inhibits YAP transcriptional activity. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 157-160 32281270-3 2020 Metformin (MET), a first-line diabetes medication that also has anti-tumour activities, induces AMP-activated protein kinase (AMPK), directly phosphorylates YAP and inhibits YAP transcriptional activity. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 174-177 32991321-8 2020 Finally, metformin, an anti-aging agent, activated the YAP-CDK6 pathway and suppressed D-gal-induced senescence of C6 cells. Metformin 9-18 Yes1 associated transcriptional regulator Homo sapiens 55-58 32407182-5 2020 Cell viability was reduced by 50% after 24 h. Data showed that metformin treatment down-regulated YAP and TAZ (p = .002) expressions and enhanced YAP phosphorylation (p < .001). Metformin 63-72 Yes1 associated transcriptional regulator Homo sapiens 98-101 32407182-5 2020 Cell viability was reduced by 50% after 24 h. Data showed that metformin treatment down-regulated YAP and TAZ (p = .002) expressions and enhanced YAP phosphorylation (p < .001). Metformin 63-72 Yes1 associated transcriptional regulator Homo sapiens 146-149 32407182-8 2020 This study showed the effects of metformin on the inhibition of oncogenic YAP and TAZ in the proliferation of melanoma cells. Metformin 33-42 Yes1 associated transcriptional regulator Homo sapiens 74-77 31906986-4 2020 However, the molecular mechanism underpinning how metformin-induced upregulation of miR-381 directly targets YAP or its interactions with the epithelial-mesenchymal transition (EMT) marker protein Snail in NSCLC is still unknown. Metformin 50-59 Yes1 associated transcriptional regulator Homo sapiens 109-112 31906986-16 2020 Furthermore, miR-381, YAP, and Snail constitute the miR-381-YAP-Snail signal axis, which is repressed by metformin, and enhances cancer cell invasiveness by directly regulating EMT. Metformin 105-114 Yes1 associated transcriptional regulator Homo sapiens 22-25 31906986-16 2020 Furthermore, miR-381, YAP, and Snail constitute the miR-381-YAP-Snail signal axis, which is repressed by metformin, and enhances cancer cell invasiveness by directly regulating EMT. Metformin 105-114 Yes1 associated transcriptional regulator Homo sapiens 60-63 31906986-17 2020 CONCLUSIONS: Metformin-induced repression of miR-381-YAP-Snail axis activity disrupts NSCLC growth and metastasis. Metformin 13-22 Yes1 associated transcriptional regulator Homo sapiens 53-56 31455378-3 2019 We are wondering if the inhibitory effect of metformin on bladder cancer is fulfilled via Yap1 and exploring the related mechanism. Metformin 45-54 Yes1 associated transcriptional regulator Homo sapiens 90-94 31814900-5 2019 Here, we showed that metformin decreases PD-L1 and YAP1 expression in vitro and in vivo. Metformin 21-30 Yes1 associated transcriptional regulator Homo sapiens 51-55 31814900-7 2019 Furthermore, metformin directly phosphorylated YAP1 and restricted YAP1 to entry in the nucleus, so that PD-L1 was reduced via western blot and immunofluorescence assays in SW480 and HCT116 cells. Metformin 13-22 Yes1 associated transcriptional regulator Homo sapiens 47-51 31814900-7 2019 Furthermore, metformin directly phosphorylated YAP1 and restricted YAP1 to entry in the nucleus, so that PD-L1 was reduced via western blot and immunofluorescence assays in SW480 and HCT116 cells. Metformin 13-22 Yes1 associated transcriptional regulator Homo sapiens 67-71 31814900-9 2019 Compared with the control group, PD-L1 and YAP1 expressions in tumor tissues, detected by immunohistochemistry, were reduced in the group of metformin treatment. Metformin 141-150 Yes1 associated transcriptional regulator Homo sapiens 43-47 31455378-0 2019 Metformin targets a YAP1-TEAD4 complex via AMPKalpha to regulate CCNE1/2 in bladder cancer cells. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 20-24 31455378-2 2019 But there are few reports on the roles of Yap1, the key molecule of Hippo pathway, in the metformin induced inhibition of bladder cancer (BLCA). Metformin 90-99 Yes1 associated transcriptional regulator Homo sapiens 42-46 31897243-0 2020 Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 86-90 31897243-4 2020 In addition, we found that the combination of metformin and LW6 increased the phosphorylation of yes-associated protein 1 at serine 127 and attenuated the nuclear localization of this transcription factor. Metformin 46-55 Yes1 associated transcriptional regulator Homo sapiens 97-121 31897243-6 2020 This suggests that metformin in combination with LW6 impairs pancreatic cancer cells and reduces nuclear localization of yes-associated protein 1. Metformin 19-28 Yes1 associated transcriptional regulator Homo sapiens 121-145 31455378-6 2019 Western Blot was performed to detect the expressions of AMPKalpha, Yap1, CCND1, CCNE1/2 and CDK2/4/6 in the metformin-treated BLCA cell lines. Metformin 108-117 Yes1 associated transcriptional regulator Homo sapiens 67-71 31455378-12 2019 And metformin upregulated the phosphorylated AMPKalpha and decreased the expressions of Yap1 and CCND1, CCNE1/2 and CDK4/6. Metformin 4-13 Yes1 associated transcriptional regulator Homo sapiens 88-92 31455378-17 2019 Furthermore, we observed that metformin inhibited the cell proliferation by decreasing the expressions of Yap1 and both CCNE1 and CCNE2 in xenograft model. Metformin 30-39 Yes1 associated transcriptional regulator Homo sapiens 106-110 31455378-18 2019 CONCLUSIONS: The results of our study reveal a new potential regulatory pathway in which metformin inhibits cell proliferation via AMPKalpha/Yap1/TEAD4/CCNE1/2 axis in BLCA cells, providing new insights into novel molecular therapeutic targets for BLCA. Metformin 89-98 Yes1 associated transcriptional regulator Homo sapiens 141-145 29567539-0 2018 Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 94-97 30389502-0 2018 The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC. Metformin 24-33 Yes1 associated transcriptional regulator Homo sapiens 48-51 30389502-0 2018 The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC. Metformin 24-33 Yes1 associated transcriptional regulator Homo sapiens 93-96 30389502-3 2018 However, the mechanism through which metformin inhibits tumorigenesis via YAP is poorly understood. Metformin 37-46 Yes1 associated transcriptional regulator Homo sapiens 74-77 30389502-10 2018 Interestingly, metformin was able to downregulate YAP mRNA and protein expression in lung cancer cells. Metformin 15-24 Yes1 associated transcriptional regulator Homo sapiens 50-53 30389502-11 2018 Mechanistically, we found that metformin depressed YAP promoter by competing with the binding of the transcription factor IRF-1 in lung cancer cells. Metformin 31-40 Yes1 associated transcriptional regulator Homo sapiens 51-54 30389502-12 2018 Moreover, combination of metformin and verteporfin synergistically inhibits cell proliferation, promotes apoptosis and suppresses cell migration/invasion by downregulating YAP, therefore reduces the side effects caused by their single use and improve the quality of life for patients with lung cancer. Metformin 25-34 Yes1 associated transcriptional regulator Homo sapiens 172-175 30389502-13 2018 INTERPRETATION: we concluded that metformin depresses YAP promoter by interfering with the binding of the transcription factor IRF-1. Metformin 34-43 Yes1 associated transcriptional regulator Homo sapiens 54-57 30389502-14 2018 Importantly, verteporfin sensitizes metformin-induced the depression of YAP and inhibition of cell growth and invasion in lung cancer cells. Metformin 36-45 Yes1 associated transcriptional regulator Homo sapiens 72-75 29567539-4 2018 Mechanistically, metformin inhibited the nuclear abundance of YAP, a key effector of Hippo pathway, subsequently leading to its cytoplasmic retention, and thus reduced YAP transcriptional modulating activity. Metformin 17-26 Yes1 associated transcriptional regulator Homo sapiens 62-65 29567539-4 2018 Mechanistically, metformin inhibited the nuclear abundance of YAP, a key effector of Hippo pathway, subsequently leading to its cytoplasmic retention, and thus reduced YAP transcriptional modulating activity. Metformin 17-26 Yes1 associated transcriptional regulator Homo sapiens 168-171 29567539-5 2018 Importantly, overexpression of a mutant form of YAP (YAP-5SA) attenuated the inhibition of metformin on glioma cells stemness and epithelial-mesenchymal transition. Metformin 91-100 Yes1 associated transcriptional regulator Homo sapiens 48-51 29567539-5 2018 Importantly, overexpression of a mutant form of YAP (YAP-5SA) attenuated the inhibition of metformin on glioma cells stemness and epithelial-mesenchymal transition. Metformin 91-100 Yes1 associated transcriptional regulator Homo sapiens 53-60 29567539-6 2018 Thus, metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity. Metformin 6-15 Yes1 associated transcriptional regulator Homo sapiens 100-103 27323827-0 2016 Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP. Metformin 0-9 Yes1 associated transcriptional regulator Homo sapiens 102-105 27323827-5 2016 Moreover, metformin repressed YAP by both decreasing the total protein expression and accelerating the phosphorylation of YAP. Metformin 10-19 Yes1 associated transcriptional regulator Homo sapiens 30-33 27323827-5 2016 Moreover, metformin repressed YAP by both decreasing the total protein expression and accelerating the phosphorylation of YAP. Metformin 10-19 Yes1 associated transcriptional regulator Homo sapiens 122-125 27323827-8 2016 Taken together, our findings suggested that metformin may increase sensitivity to chemotherapeutic agents by suppressing YAP in hepatocellular carcinoma. Metformin 44-53 Yes1 associated transcriptional regulator Homo sapiens 121-124