PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18673148-8	2008	We observed that metformin, besides its antihyperglycemic action, induces a significant decrease in TBARS and MDA levels, GPx and GRed activities and a significant increase in GSH levels and MnSOD activity.	Metformin	17-26	superoxide dismutase 2	Rattus norvegicus	191-196	
24762600-10	2014	Knockdown of SIRT3 (P < 0.05) reversed the metformin-induced decreases in NF-kappaB p65 and JNK1 and the metformin-induced increase in SOD2 (P < 0.05).	Metformin	108-117	superoxide dismutase 2	Rattus norvegicus	138-142	
34464747-14	2021	DF-induced mitochondrial dysfunction which was demonstrated by decreased oxygen consumption rate, an increased ROS production and a reduced MnSOD level, were all reversed by metformin in an EPAC-dependent manner.	Metformin	174-183	superoxide dismutase 2	Rattus norvegicus	140-145	
33174032-10	2020	In addition, metformin stimulated mitochondrial biogenesis, as indicated by increased expression levels of mitochondrial genes (NDUFA1, NDUFA2, NDUFA13 and manganese superoxide dismutase) and mitochondrial biogenesis-related transcription factors [peroxisome proliferator-activated receptor-gamma coactivator-1alpha, nuclear respiratory factor (NRF)-1, and NRF-2] in the metformin + HG group compared with the HG group.	Metformin	13-22	superoxide dismutase 2	Rattus norvegicus	156-186	
24762600-9	2014	Metformin increased the expression of SIRT3 (1.5-fold) and SOD2 (2-fold) while down regulating NF-kappaB p65 (1.5-fold) and JNK1 (1.5-fold).	Metformin	0-9	superoxide dismutase 2	Rattus norvegicus	59-63