PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33849997-5 2021 Metformin has beneficial effects in humans in tissues with high levels of mGPD such as pancreatic beta cells where mGPD is much higher than in liver. Metformin 0-9 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 74-78 33849997-5 2021 Metformin has beneficial effects in humans in tissues with high levels of mGPD such as pancreatic beta cells where mGPD is much higher than in liver. Metformin 0-9 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 115-119 33849997-7 2021 For these and other reasons we used four different enzyme assays to reassess whether metformin inhibited mGPD. Metformin 85-94 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 105-109 33849997-9 2021 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin 3-12 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 32-36 33849997-9 2021 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin 3-12 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 84-88 33849997-9 2021 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin 132-141 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 32-36 33849997-9 2021 If metformin actually inhibited mGPD, adverse effects in tissues where the level of mGPD is much higher than in liver could prevent metformin"s use as a diabetes medicine. Metformin 132-141 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 84-88 25808533-3 2015 The reduction of gluconeogenesis evoked by metformin may be a result of an energy deficit evoked through the inhibition of mitochondrial respiratory chain complex I and/or increased cytosolic redox state and decreased mitochondrial redox state elicited by the inhibition of mitochondrial glycerophosphate dehydrogenase (mGPD). Metformin 43-52 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 320-324 25808533-5 2015 Recently, it was reported that inhibition of mGPD by metformin decreases the level of dihydroxyacetone phosphate and reduces the conversion of lactate to pyruvate, that in consequence diminishes the utilization of glycerol and lactate for gluconeogenesis. Metformin 53-62 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 45-49