PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32780768-6	2020	Moreover, we found a significant upregulation of IRS2 gene (log2FC 0.89) in responders compared to non-responders before the use of metformin.	Metformin	132-141	insulin receptor substrate 2	Homo sapiens	49-53	
22643892-8	2012	Among the messenger RNAs downregulated by metformin, we found c-MYC, IRS-2 and HIF1alpha.	Metformin	42-51	insulin receptor substrate 2	Homo sapiens	69-74	
28990055-7	2017	The results demonstrated that IRS-2 and PI3K expression was markedly decreased in PCOS ovaries, which was rescued by DMBG treatment.	Metformin	117-121	insulin receptor substrate 2	Homo sapiens	30-35	
28990055-8	2017	These results indicate that IRS-2/PI3K signaling may be involved in the development of PCOS and the therapeutic effects of DMBG on PCOS.	Metformin	123-127	insulin receptor substrate 2	Homo sapiens	28-33	
24980829-7	2014	Additionally, metformin modulated the levels of c-MYC and IRS-2, and this correlated with changes of the microRNA-33a levels.	Metformin	14-23	insulin receptor substrate 2	Homo sapiens	58-63	
12629126-0	2003	Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.	Metformin	0-9	insulin receptor substrate 2	Homo sapiens	106-134	
21801267-7	2011	Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant.	Metformin	15-24	insulin receptor substrate 2	Homo sapiens	86-91	
12629126-7	2003	Metformin (1 micro g/ml) increased IR tyrosine phosphorylation by 78% (P = 0.0007) in 30 min in human hepatocytes and Huh7 cells and increased IRS-2 but not IRS-1 activation, and the downstream increase in deoxyglucose uptake was mediated via increased translocation of GLUT-1 to the plasma membrane.	Metformin	0-9	insulin receptor substrate 2	Homo sapiens	143-148	
12629126-11	2003	This study demonstrates that the mechanism of action of metformin in liver involves IR activation, followed by selective IRS-2 activation, and increased glucose uptake via increased GLUT-1 translocation.	Metformin	56-65	insulin receptor substrate 2	Homo sapiens	121-126	
12511230-5	2003	Tyrosine phosphorylation of IR?, IRS1, and IRS2 was increased by 2.7 fold (P < 0.01), 6.8 fold (P < 0.01), and 2.3 fold (P <0.01) of chronically insulin-treated cells alone, respectively, after metformin 0.1 mmol/L was added.	Metformin	203-212	insulin receptor substrate 2	Homo sapiens	43-47	
12511230-7	2003	In contrast, metformin in pharmacological concentration (1-10 mmol/L) further inhibited tyrosine phosphorylation of IR?, IRS1, IRS2 and the interaction of PI3K with IRS.	Metformin	13-22	insulin receptor substrate 2	Homo sapiens	127-131