PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26990999-0	2016	Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.	Metformin	0-9	dicer 1, ribonuclease type III	Mus musculus	31-37	
26990999-4	2016	Here, we show that metformin treatment increases the levels of the microRNA-processing protein DICER1 in mice and in humans with diabetes mellitus.	Metformin	19-28	dicer 1, ribonuclease type III	Mus musculus	95-101	
26990999-5	2016	Our results indicate that metformin upregulates DICER1 through a post-transcriptional mechanism involving the RNA-binding protein AUF1.	Metformin	26-35	dicer 1, ribonuclease type III	Mus musculus	48-54	
26990999-6	2016	Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate.	Metformin	15-24	dicer 1, ribonuclease type III	Mus musculus	103-109	
26990999-6	2016	Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate.	Metformin	15-24	dicer 1, ribonuclease type III	Mus musculus	129-135	
26990999-6	2016	Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate.	Metformin	15-24	dicer 1, ribonuclease type III	Mus musculus	129-135	
26990999-7	2016	Consistent with the role of DICER1 in the biogenesis of microRNAs, we found differential patterns of microRNA expression in mice treated with metformin or caloric restriction, two proven life-extending interventions.	Metformin	142-151	dicer 1, ribonuclease type III	Mus musculus	28-34	
26990999-9	2016	In agreement with these findings, treatment with metformin decreased cellular senescence in several senescence models in a DICER1-dependent manner.	Metformin	49-58	dicer 1, ribonuclease type III	Mus musculus	123-129	
26990999-11	2016	These data lead us to hypothesize that changes in DICER1 levels may be important for organismal aging and to propose that interventions that upregulate DICER1 expression (e.g., metformin) may offer new pharmacotherapeutic approaches for age-related disease.	Metformin	177-186	dicer 1, ribonuclease type III	Mus musculus	152-158