PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28193839-4 2017 We further show that metformin promoted DeltaNp63alpha protein instability independent of AMP-activated protein kinase and that WWP1, an E3 ligase of DeltaNp63alpha, was involved in metformin-mediated down-regulation of DeltaNp63alpha levels. Metformin 182-191 WW domain containing E3 ubiquitin protein ligase 1 Homo sapiens 128-132