PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32646922-11	2020	In both humans and mice, metformin triggered AMPK activation and STAT3 inactivation, and altered the production of effector cytokines (i.e. TNF-alpha, IFN-gamma, IL-10) in the immune cells.	Metformin	25-34	interferon gamma	Homo sapiens	151-160	
34236726-0	2022	Effects of metformin on autoimmune immunoglobins and interferon-gamma in patients with early diagnosed pemphigus vulgaris: A prospective clinical trial.	Metformin	11-20	interferon gamma	Homo sapiens	53-69	
33444083-8	2021	We observed that participants on 3000 mg/day dose of metformin had significantly lower levels of TNF-alpha (p < .001) and IFN-gamma (p = .014) compared to those on other dosages (1000 mg and 2000 mg/day).	Metformin	53-62	interferon gamma	Homo sapiens	122-131	
34887262-11	2021	SN-38 or metformin sensitized unresponsive tumors responding to anti-PD-1 therapy by engaging NK or CD8+ T cells to infiltrate the tumor microenvironment (TME) and secret interferon-gamma and granzyme B to kill tumors.	Metformin	9-18	interferon gamma	Homo sapiens	171-187	
30753544-6	2019	At a functional level, metformin lowered ex vivo production of tumor necrosis factor alpha, interferon gamma, and interleukin 1beta but increased phagocytosis activity and reactive oxygen species production.	Metformin	23-32	interferon gamma	Homo sapiens	92-108	
32533334-11	2020	Furthermore, IFNgamma expression appeared to be increased in response to metformin (p = 0.08).	Metformin	73-82	interferon gamma	Homo sapiens	13-21	
32641388-4	2020	In this study, we report that metformin + 2-DG treatment more potently suppressed IFN-gamma production and cell proliferation in activated primary human CD4+ T cells than either metformin or 2-DG treatment alone.	Metformin	30-39	interferon gamma	Homo sapiens	82-91	
25673763-8	2015	Further, CD4(+) T cells from SLE patients also exhibited enhanced glycolysis and mitochondrial metabolism that correlated with their activation status, and their excessive IFN-gamma production was significantly reduced by metformin in vitro.	Metformin	222-231	interferon gamma	Homo sapiens	172-181	
23744427-6	2013	RESULTS: Beyond improving glucose homeostasis, metformin reduced plasma C-reactive protein levels and lymphocyte release of tumor necrosis factor-alpha and interferon-gamma, as well as tended to reduce interleukin-2 release and plasma intercellular adhesion molecule-1.	Metformin	47-56	interferon gamma	Homo sapiens	156-172	
23107042-5	2012	Metformin, but not placebo, administered to simvastatin-treated IFG subjects reduced plasma levels of C-reactive protein, soluble intercellular adhesion molecule-1, as well as lymphocyte release of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, which was accompanied by the improvement in insulin sensitivity and a reduction in free fatty acid levels.	Metformin	0-9	interferon gamma	Homo sapiens	213-261	
31235122-6	2019	Glycemic control, most treated diabetic patients with metformin mono- and dual therapies showed an ameliorative effect in HbA1c, IFN-gamma, MPV, and PDW values compared to recent diabetic ones.	Metformin	54-63	interferon gamma	Homo sapiens	129-138	
19494326-3	2009	We provide evidence that metformin attenuates the induction of EAE by restricting the infiltration of mononuclear cells into the CNS, down-regulating the expression of proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules, matrix metalloproteinase 9, and chemokine (RANTES).	Metformin	25-34	interferon gamma	Homo sapiens	195-204