PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29256045-0	2018	Metformin Promotes 2-Deoxy-2-[18F]Fluoro-D-Glucose Uptake in Hepatocellular Carcinoma Cells Through FoxO1-Mediated Downregulation of Glucose-6-Phosphatase.	Metformin	0-9	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	133-154	
22758368-4	2012	Adenosine monophosphate kinase (AMPK) agonists such as metformin, which inhibits gluconeogenesis by downregulating expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, might be expected to block the glucose dysmetabolism mediated by rapamycin.	Metformin	55-64	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	129-150	
19579180-7	2009	In contrast, under conditions of stimulation with dexamethasone and cAMP, treatment with compound C reversed the inhibitory effect of metformin on G6Pase promoter activity to a similar extent as compared to nonstimulated conditions, whereas the effect of insulin was almost resistant to treatment with the AMPK-antagonist.	Metformin	134-143	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	147-153	
19579180-8	2009	These data indicate a differential AMPK-dependent regulation of G6Pase gene expression by insulin and metformin under basal and dexamethasone/cAMP-stimulated conditions.	Metformin	102-111	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	64-70	
28206714-9	2017	Metformin counteracted the effect of high glucose on the elevated G6P and fructose 2,6-bisphosphate and on Gck repression, recruitment of Mlx-ChREBP to the G6pc and Pklr promoters and induction of these genes.	Metformin	0-9	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	156-160	
19579180-0	2009	Regulation of glucose-6-phosphatase gene expression by insulin and metformin.	Metformin	67-76	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	14-35	
19579180-3	2009	Since the mechanisms of metformin action are only partially understood at the molecular level, we studied the regulation of the gene promoter activity of glucose-6-phosphatase (G6Pase), the central hepatic gluconeogenic enzyme, by this drug.	Metformin	24-33	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	154-175	
19579180-3	2009	Since the mechanisms of metformin action are only partially understood at the molecular level, we studied the regulation of the gene promoter activity of glucose-6-phosphatase (G6Pase), the central hepatic gluconeogenic enzyme, by this drug.	Metformin	24-33	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	177-183	
19579180-4	2009	We have found that both metformin and insulin inhibit the basal and dexamethasone/cAMP-stimulated G6Pase promoter activity in hepatoma cells.	Metformin	24-33	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	98-104	
10576523-5	1999	In addition, metformin can reduce the overall rate of glycogenolysis and decrease the activity of hepatic glucose-6-phosphatase.	Metformin	13-22	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	106-127	
32375255-7	2020	The metabolite changes caused by metformin may also have a prominent role in counteracting G6pc gene regulation in conditions of compromised intracellular homeostasis.	Metformin	33-42	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	91-95