PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35528855-5 2022 This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. Metformin 56-65 V-set immunoregulatory receptor Homo sapiens 69-74 35528855-7 2022 Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. Metformin 6-15 V-set immunoregulatory receptor Homo sapiens 40-45 35528855-13 2022 These findings demonstrate for the first time that VISTA is suppressed by metformin and identified a new regulatory mechanism through AHR. Metformin 74-83 V-set immunoregulatory receptor Homo sapiens 51-56