PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25681557-0	2015	Metformin ameliorates acetaminophen hepatotoxicity via Gadd45beta-dependent regulation of JNK signaling in mice.	Metformin	0-9	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	55-65	
27562556-3	2016	(2015, Metformin ameliorates acetaminophen hepatotoxicity via Gadd45beta-dependent regulation of JNK signaling in mice.	Metformin	7-16	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	62-72	
25681557-13	2015	CONCLUSIONS: This study is the first to demonstrate that metformin shows protective and therapeutic effects against APAP overdose-evoked hepatotoxicity via Gadd45beta-dependent JNK regulation.	Metformin	57-66	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	156-166	
25681557-5	2015	METHODS: We used APAP- and/or metformin-treated Gadd45beta knockout (KO) mice and wild type (WT) C57BL/6J control mice.	Metformin	30-39	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	48-58	
25681557-8	2015	Gadd45beta expression was increased after APAP treatment, and the expression of Gadd45beta was further enhanced by metformin.	Metformin	115-124	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	80-90	
25681557-9	2015	The effects of metformin on APAP-induced liver injury and JNK phosphorylation were abolished in Gadd45beta KO mice.	Metformin	15-24	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	96-106