PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25053715-12 2015 Among the KLF5/GATA4/GATA6 direct target genes relevant for cancer development, one target gene, HNF4alpha, was also required for GC proliferation and could be targeted by the antidiabetic drug metformin, revealing a therapeutic opportunity for KLF5/GATA4/GATA6 amplified GCs. Metformin 194-203 GATA binding protein 6 Mus musculus 256-261 25053715-12 2015 Among the KLF5/GATA4/GATA6 direct target genes relevant for cancer development, one target gene, HNF4alpha, was also required for GC proliferation and could be targeted by the antidiabetic drug metformin, revealing a therapeutic opportunity for KLF5/GATA4/GATA6 amplified GCs. Metformin 194-203 GATA binding protein 6 Mus musculus 21-26 25127677-12 2014 Metformin prevented nicotine-induced pancreatic carcinogenesis and tumor growth by up-regulating GATA6 and promoting differentiation toward an acinar cell program. Metformin 0-9 GATA binding protein 6 Mus musculus 97-102