PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35550195-9 2022 Signal transduction analysis of the paired cell lines indicated that c-Met-induced activation of STAT3 and AKT1, and upregulation of Gab1 are related to c-Met-modulated metformin responsiveness. Metformin 169-178 GRB2 associated binding protein 1 Homo sapiens 133-137 32041944-0 2020 Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1. Metformin 0-9 GRB2 associated binding protein 1 Homo sapiens 76-80 32041944-7 2020 The antidiabetic drug metformin combined with alectinib overcame alectinib resistance triggered by HGF/MET through disrupting the complex between MET and Gab1, thereby inhibiting Gab1 phosphorylation and the activation of downstream signal transduction pathways. Metformin 22-31 GRB2 associated binding protein 1 Homo sapiens 154-158 32041944-7 2020 The antidiabetic drug metformin combined with alectinib overcame alectinib resistance triggered by HGF/MET through disrupting the complex between MET and Gab1, thereby inhibiting Gab1 phosphorylation and the activation of downstream signal transduction pathways. Metformin 22-31 GRB2 associated binding protein 1 Homo sapiens 179-183