PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21159854-0	2011	Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.	Metformin	149-158	gonadotropin releasing hormone 1	Mus musculus	83-113	
18194429-6	2008	Treatment with AICAR (5 mM) or metformin (5 mM) for 4 h inhibited GnRH release in the presence or absence of GnRH (10(-8) M).	Metformin	31-40	gonadotropin releasing hormone 1	Mus musculus	66-70	
18194429-6	2008	Treatment with AICAR (5 mM) or metformin (5 mM) for 4 h inhibited GnRH release in the presence or absence of GnRH (10(-8) M).	Metformin	31-40	gonadotropin releasing hormone 1	Mus musculus	109-113	
18194429-7	2008	Specific AMPK inhibitor compound C completely eliminated the effects of AICAR or metformin on GnRH release.	Metformin	81-90	gonadotropin releasing hormone 1	Mus musculus	94-98	
21159854-10	2011	GnRH neurons from metformin-treated mice also showed a reduced inhibitory response to low glucose.	Metformin	18-27	gonadotropin releasing hormone 1	Mus musculus	0-4	
21159854-0	2011	Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.	Metformin	149-158	gonadotropin releasing hormone 1	Mus musculus	115-119	
21159854-8	2011	To assess whether AMPK activation contributed to the metformin-induced reduction in GnRH neuron activity, the AMPK antagonist compound C was acutely applied to cells.	Metformin	53-62	gonadotropin releasing hormone 1	Mus musculus	84-88