PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31342643-0	2020	SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors.	Metformin	22-31	inositol polyphosphate phosphatase like 1	Homo sapiens	57-62	
31342643-7	2020	One of the newly identified SHIP2 inhibitors is metformin, the first-line medication prescribed to patients with type 2 diabetes, further boosting the attraction of SHIP2 as a treatment target to ameliorate metabolic disorders.	Metformin	48-57	inositol polyphosphate phosphatase like 1	Homo sapiens	28-33	
31342643-7	2020	One of the newly identified SHIP2 inhibitors is metformin, the first-line medication prescribed to patients with type 2 diabetes, further boosting the attraction of SHIP2 as a treatment target to ameliorate metabolic disorders.	Metformin	48-57	inositol polyphosphate phosphatase like 1	Homo sapiens	165-170	
30321069-0	2019	Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.	Metformin	0-9	inositol polyphosphate phosphatase like 1	Homo sapiens	73-78	
30321069-4	2019	Here, we demonstrate that metformin directly binds to and reduces the catalytic activity of the recombinant SHIP2 phosphatase domain in vitro.	Metformin	26-35	inositol polyphosphate phosphatase like 1	Homo sapiens	108-113	
30321069-6	2019	In SHIP2-overexpressing myotubes, metformin ameliorates reduced glucose uptake by slowing down glucose transporter 4 endocytosis.	Metformin	34-43	inositol polyphosphate phosphatase like 1	Homo sapiens	3-8	
30321069-7	2019	SHIP2 overexpression reduces Akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin.	Metformin	117-126	inositol polyphosphate phosphatase like 1	Homo sapiens	0-5	
30321069-8	2019	SHIP2 activity is elevated in glomeruli of patients with T2D receiving nonmetformin medication, but not in patients receiving metformin, compared with people without diabetes.	Metformin	74-83	inositol polyphosphate phosphatase like 1	Homo sapiens	0-5	
32741295-4	2021	Similar to metformin, the PolyMet-HA nanocomplexs could reduce the catalytic activity of the recombinant SHIP2 phosphatase domain in vitro.	Metformin	11-20	inositol polyphosphate phosphatase like 1	Homo sapiens	105-110