PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32741295-4 2021 Similar to metformin, the PolyMet-HA nanocomplexs could reduce the catalytic activity of the recombinant SHIP2 phosphatase domain in vitro. Metformin 11-20 inositol polyphosphate phosphatase like 1 Homo sapiens 105-110 31342643-0 2020 SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors. Metformin 22-31 inositol polyphosphate phosphatase like 1 Homo sapiens 57-62 31342643-7 2020 One of the newly identified SHIP2 inhibitors is metformin, the first-line medication prescribed to patients with type 2 diabetes, further boosting the attraction of SHIP2 as a treatment target to ameliorate metabolic disorders. Metformin 48-57 inositol polyphosphate phosphatase like 1 Homo sapiens 28-33 31342643-7 2020 One of the newly identified SHIP2 inhibitors is metformin, the first-line medication prescribed to patients with type 2 diabetes, further boosting the attraction of SHIP2 as a treatment target to ameliorate metabolic disorders. Metformin 48-57 inositol polyphosphate phosphatase like 1 Homo sapiens 165-170 30321069-0 2019 Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. Metformin 0-9 inositol polyphosphate phosphatase like 1 Homo sapiens 73-78 30321069-4 2019 Here, we demonstrate that metformin directly binds to and reduces the catalytic activity of the recombinant SHIP2 phosphatase domain in vitro. Metformin 26-35 inositol polyphosphate phosphatase like 1 Homo sapiens 108-113 30321069-6 2019 In SHIP2-overexpressing myotubes, metformin ameliorates reduced glucose uptake by slowing down glucose transporter 4 endocytosis. Metformin 34-43 inositol polyphosphate phosphatase like 1 Homo sapiens 3-8 30321069-7 2019 SHIP2 overexpression reduces Akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin. Metformin 117-126 inositol polyphosphate phosphatase like 1 Homo sapiens 0-5 30321069-8 2019 SHIP2 activity is elevated in glomeruli of patients with T2D receiving nonmetformin medication, but not in patients receiving metformin, compared with people without diabetes. Metformin 74-83 inositol polyphosphate phosphatase like 1 Homo sapiens 0-5