PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27737949-0	2017	Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission.	Metformin	0-9	dynamin 1-like	Mus musculus	80-84	
33968030-6	2021	Mechanistically, metformin treatment modulated the phosphorylation of dynamin-related protein 1 (Drp-1) and mitochondrial fission 1 protein (FIS1), resulting in increased mass in effector T cells.	Metformin	17-26	dynamin 1-like	Mus musculus	70-95	
33968030-6	2021	Mechanistically, metformin treatment modulated the phosphorylation of dynamin-related protein 1 (Drp-1) and mitochondrial fission 1 protein (FIS1), resulting in increased mass in effector T cells.	Metformin	17-26	dynamin 1-like	Mus musculus	97-102	
27737949-5	2017	In high glucose-exposed endothelial cells, metformin treatment and adenoviral overexpression of constitutively active AMPK downregulated mitochondrial superoxide, lowered levels of dynamin-related protein (Drp1) and its translocation into mitochondria, and prevented mitochondrial fragmentation.	Metformin	43-52	dynamin 1-like	Mus musculus	206-210	
27737949-6	2017	In contrast, AMPK-alpha2 deficiency abolished the effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis in diabetic ApoE-/-/AMPK-alpha2-/- mice, indicating that metformin exerts an antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.	Metformin	61-70	dynamin 1-like	Mus musculus	74-78	
27737949-6	2017	In contrast, AMPK-alpha2 deficiency abolished the effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis in diabetic ApoE-/-/AMPK-alpha2-/- mice, indicating that metformin exerts an antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.	Metformin	61-70	dynamin 1-like	Mus musculus	275-279	
27737949-8	2017	These findings show that metformin attenuated the development of atherosclerosis by reducing Drp1-mediated mitochondrial fission in an AMPK-dependent manner.	Metformin	25-34	dynamin 1-like	Mus musculus	93-97	
35395467-7	2022	In addition, metformin therapy increased mitochondrial membrane potential, with a reduction in mitochondrial reactive oxygen species, MDA and SOD levels, and restored mitochondrial balance through enhanced expression of dynamin-related protein 1 (Drp1).	Metformin	13-22	dynamin 1-like	Mus musculus	220-245	
35395467-7	2022	In addition, metformin therapy increased mitochondrial membrane potential, with a reduction in mitochondrial reactive oxygen species, MDA and SOD levels, and restored mitochondrial balance through enhanced expression of dynamin-related protein 1 (Drp1).	Metformin	13-22	dynamin 1-like	Mus musculus	247-251	
35392573-0	2022	Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1.	Metformin	0-9	dynamin 1-like	Mus musculus	110-114