PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26962099-7	2016	Metformin, an AMPK activator, increased phosphorylation of both AQP2 and UT-A1 in rat inner medullary collecting ducts (IMCDs).	Metformin	0-9	aquaporin 2	Rattus norvegicus	64-68	
26962099-8	2016	Metformin increased the apical plasma membrane accumulation of AQP2, but not UT-A1, in rat IM.	Metformin	0-9	aquaporin 2	Rattus norvegicus	63-67	
26962099-10	2016	These findings suggest that metformin increases osmotic water permeability by increasing AQP2 accumulation in the apical plasma membrane but increases urea permeability by activating UT-A1 already present in the membrane.	Metformin	28-37	aquaporin 2	Rattus norvegicus	89-93	
34595852-10	2021	Tissue AQP2 levels decreased with lithium administration but stabilized with metformin treatment.	Metformin	77-86	aquaporin 2	Rattus norvegicus	7-11	
34595852-12	2021	CONCLUSIONS: Metformin may help protect the kidneys from lithium-induced NDI through the AQP2 regulating effect and a reduction in oxidative stress.	Metformin	13-22	aquaporin 2	Rattus norvegicus	89-93	
30427219-11	2019	When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together.	Metformin	109-118	aquaporin 2	Rattus norvegicus	129-133	
30427219-11	2019	When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together.	Metformin	185-194	aquaporin 2	Rattus norvegicus	129-133	
30427219-11	2019	When inner medullary tissue was treated with the PKC activator phorbol dibutyrate (PDBu), the AMPK activator metformin, or both, AQP2 phosphorylation at S261 was decreased with PDBu or metformin alone, but there was no additive effect on phosphorylation with PDBu and metformin together.	Metformin	185-194	aquaporin 2	Rattus norvegicus	129-133	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Metformin	0-9	aquaporin 2	Rattus norvegicus	91-102	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Metformin	0-9	aquaporin 2	Rattus norvegicus	104-108	
27478876-8	2016	Metformin increased protein abundance of inner medullary urea transporter UT-A1 by 61% and aquaporin 2 (AQP2) by 44% in tolvaptan-treated rats, and immunohistochemistry showed increased membrane accumulation of AQP2 with acute and chronic AMPK stimulation.	Metformin	0-9	aquaporin 2	Rattus norvegicus	211-215