PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29278707-15	2018	Metformin ameliorated steatohepatitis, liver fibrosis, inflammatory cytokine production and decreased alpha -SMA and GPR91expression in the livers of the MCD diet-fed mice.	Metformin	0-9	actin alpha 2, smooth muscle, aorta	Mus musculus	102-112	
31852643-6	2019	In animal model, The staining of alpha-SMA showed smooth muscle cells migrated to the intima or even to the lipid area from the media of aorta in CTL group compared to the Met group.	Metformin	172-175	actin alpha 2, smooth muscle, aorta	Mus musculus	33-42	
34002012-10	2021	When cells were treated with metformin (an AMPK activator), the CRBN-induced activation of SMAD3 and upregulation of alpha-SMA and collagen expression were significantly suppressed, suggesting that increased TGF-beta1-induced activation of SMAD3 via CRBN overexpression is associated with AMPKalpha1 inactivation.	Metformin	29-38	actin alpha 2, smooth muscle, aorta	Mus musculus	117-126	
28390311-6	2017	However, treatment with metformin suppressed CCl4-induced expression of transforming growth factor beta 1 (TGF-beta1) and phosphorylation of Smad3, which was accompanied with decreased level of alpha smooth muscle actin (alpha-SMA), a marker for the activated hepatic stellate cells (HSCs).	Metformin	24-33	actin alpha 2, smooth muscle, aorta	Mus musculus	194-219	
28390311-6	2017	However, treatment with metformin suppressed CCl4-induced expression of transforming growth factor beta 1 (TGF-beta1) and phosphorylation of Smad3, which was accompanied with decreased level of alpha smooth muscle actin (alpha-SMA), a marker for the activated hepatic stellate cells (HSCs).	Metformin	24-33	actin alpha 2, smooth muscle, aorta	Mus musculus	221-230	
28409163-13	2017	AICAR and metformin treatment effectively mitigated albuminuria and renal histopathology and decreased the expression of TGFbeta1 and alphaSMA in the kidneys of diabetic mice.	Metformin	10-19	actin alpha 2, smooth muscle, aorta	Mus musculus	134-142	
34502314-8	2021	Moreover, metformin resulted in reduced expression of COL3A1, alphaSMA and CD68 after 14 days of reperfusion.	Metformin	10-19	actin alpha 2, smooth muscle, aorta	Mus musculus	62-70