PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34964193-2 2022 Metformin (MET) is a commonly used antidiabetic drug with multiple properties including antiproliferative activity, antioxidant potency, and is used in polycystic ovarian syndrome treatment. Metformin 11-14 SAFB like transcription modulator Homo sapiens 0-9 33773207-1 2021 BACKGROUND: Metformin (MET) may exert anti-rheumatic effects and reduce cartilage degradation through its immunomodulatory and anti-inflammatory actions. Metformin 12-21 SAFB like transcription modulator Homo sapiens 23-26 34944532-1 2021 It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). Metformin 120-129 SAFB like transcription modulator Homo sapiens 131-134 34531248-1 2021 BACKGROUND: Metformin (Met) is the first-line treatment for type 2 diabetes mellitus and plays an effective role in treating various diseases, such as cardiovascular disease, neurodegenerative disease, cancer, and aging. Metformin 12-21 SAFB like transcription modulator Homo sapiens 23-26 34629300-2 2021 Several retrospective studies suggested a decrease in Prostate Cancer incidence and mortality with metformin (MET). Metformin 99-108 SAFB like transcription modulator Homo sapiens 110-113 34834341-1 2021 The mechanochemical synthesis of drug-drug solid forms containing metformin hydrochloride (MET HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported. Metformin 66-89 SAFB like transcription modulator Homo sapiens 91-94 34572545-2 2021 In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug-metformin hydrochloride (MET). Metformin 163-186 SAFB like transcription modulator Homo sapiens 188-191 34569406-2 2021 In this investigation, the combination of cisplatin (CPT) and metformin (MET) to kill the HepG2 and caco-2 cells was developed into a new pH-responding magnetic nanocomposite based on reduced graphene oxide. Metformin 62-71 SAFB like transcription modulator Homo sapiens 73-76 34479029-2 2021 The anti-diabetic agent metformin (MET) and the aspirin metabolite salicylate (SAL) are shown to activate AMP-activated protein kinase (AMPK), suppress de novo lipogenesis (DNL), the mammalian target of rapamycin (mTOR) pathway and reduce PrCa proliferation in-vitro. Metformin 24-33 SAFB like transcription modulator Homo sapiens 35-38 35503619-4 2022 Metformin (Met) is one of the most common drugs affecting the most relevant genes involved in PCOS development but with unwanted side effects. Metformin 0-9 SAFB like transcription modulator Homo sapiens 11-14 35460908-2 2022 Metformin (Met) is a promising drug for tumor treatment that targets hexokinase 2 (HK2) to block the glycolytic process, thereby further disrupting the metabolism of cancer cells. Metformin 0-9 SAFB like transcription modulator Homo sapiens 11-14 34130731-3 2021 The VERIFY study in patients with newly diagnosed T2DM (across 34 countries), assessed the normoglycemic durability (5 years), with early combination (EC) therapy approach versus the traditional stepwise approach of initiating treatment with metformin monotherapy (MET). Metformin 242-251 SAFB like transcription modulator Homo sapiens 265-268 35501295-1 2022 We aimed to investigating the effects of metformin (MET) in combination with alpha lipoic acid (ALA) on hormonal and biochemical parameters, in polycystic ovary syndrome (PCOS) women undergoing intracytoplasmic sperm injection (ICSI). Metformin 41-50 SAFB like transcription modulator Homo sapiens 52-55 35388027-2 2022 Metformin hydrochloride (MET) is a highly soluble oral antidiabetic drug of small size and high cationic charge. Metformin 0-23 SAFB like transcription modulator Homo sapiens 25-28 35286856-1 2022 Here, inspired by the concept of supramolecular inclusion complex, we successfully fabricate metformin (Met)-based supramolecular nanodrugs with the Abeta-responsive on-demand drug release for synergistic Alzheimer"s disease (AD) therapy via enhancing microglial Abeta clearance. Metformin 93-102 SAFB like transcription modulator Homo sapiens 104-107 33152427-4 2021 AIM OF THE STUDY: This study was designed to investigate the efficacy and underlying mechanisms of HKC combined with metformin (MET), the first-line medication for treating type 2 diabetes, in the treatment of renal interstitial fibrosis. Metformin 117-126 SAFB like transcription modulator Homo sapiens 128-131 35104599-1 2022 Metformin hydrochloride (MET-HCl) was applied as a model compound to investigate the nucleation behavior in four hydroxylic solvents based on the experimental and simulated methods. Metformin 0-23 SAFB like transcription modulator Homo sapiens 25-28 35309430-0 2022 Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K. Metformin hydrochloride (MET HCl) is one of the most widely used oral hypoglycemic drugs in the world. Metformin 47-70 SAFB like transcription modulator Homo sapiens 148-151 35309430-0 2022 Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K. Metformin hydrochloride (MET HCl) is one of the most widely used oral hypoglycemic drugs in the world. Metformin 123-146 SAFB like transcription modulator Homo sapiens 148-151 35085591-2 2022 Metformin (MET) is considered as the first-line therapy for patients with type 2 diabetes (T2D). Metformin 0-9 SAFB like transcription modulator Homo sapiens 11-14 35186762-6 2022 The aim of this study was to investigate the metabolic alterations associated with metformin (MET), an anti-diabetic agent when combined with two antifolate drugs: trimethoprim (TMP) or methotrexate (MTX), and how metabolic changes within the cancer cell may be used to increase cellular death. Metformin 94-97 SAFB like transcription modulator Homo sapiens 83-92 35013152-4 2022 This study aimed to assess the underlying mechanism of the formation of ARC and investigate the potential anti-ageing effect of metformin (MET) on ARC. Metformin 128-137 SAFB like transcription modulator Homo sapiens 139-142 33830437-0 2021 Metformin in non-diabetic patients with metabolic syndrome and diastolic dysfunction: the MET-DIME randomized trial. Metformin 0-9 SAFB like transcription modulator Homo sapiens 90-93 33935082-6 2021 RESULTS: Dual therapy with metformin (Met) + dipeptidyl peptidase-4 inhibitor (DPP-4i), Met + thiazolidinedione (TZD), and sulfonylurea (SU) + thiazolidinediones (TZD) were significantly associated with all-cause dementia (HR = 0.904, 0.804, and 0.962, respectively) and VaD (HR = 0.865, 0.725, and 0.911, respectively), compared with Met + SU. Metformin 27-36 SAFB like transcription modulator Homo sapiens 38-41 33888740-4 2021 In this sense, Metformin (MET), an FDA-approved drug used for the treatment of type 2 diabetes, has shown an anti-DENV effect in vitro by activating AMPK and reducing HMGCR activity. Metformin 15-24 SAFB like transcription modulator Homo sapiens 26-29 33685669-3 2021 Metformin (MET) is typically prescribed as first-line therapy, but a second line is often needed, given MET can be insufficient for maintaining long-term glycemic control. Metformin 0-9 SAFB like transcription modulator Homo sapiens 11-14 33347290-3 2021 In this study, a novel GBR membrane with polycaprolactone (PCL) and poly(vinyl alcohol) (PVA) containing different concentrations of metformin (Met) for improving osteogenic properties was developed. Metformin 133-142 SAFB like transcription modulator Homo sapiens 144-147 33458460-1 2021 An expired metformin drug (MET) was used as a corrosion inhibitor for C1018 carbon steel in a CO2-saturated 3.5 wt % NaCl + 340 ppm acetic acid solution under static conditions. Metformin 11-20 SAFB like transcription modulator Homo sapiens 27-30 33080281-4 2020 The present study shows new approaches of metformin (MET) as an antioxidant agent. Metformin 42-51 SAFB like transcription modulator Homo sapiens 53-56 35203060-3 2022 As a classic hypoglycemic drug, metformin (MET) can be used as a treatment strategy for COPD due to its anti-inflammatory and antioxidant effects, but its specific mechanism of action is not known. Metformin 32-41 SAFB like transcription modulator Homo sapiens 43-46 35348721-4 2022 OBJECTIVE: Three simple, accurate, and sensitive methods have been developed and validated for the determination of canagliflozin (CANA); one is a stability-indicating method for CANA and metformin (MET) determination. Metformin 188-197 SAFB like transcription modulator Homo sapiens 199-202 35216470-1 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. Metformin 109-118 SAFB like transcription modulator Homo sapiens 120-123 35056573-3 2022 The antibacterial effect of the combination of Triton X-100 (TX-100) and metformin (Met) on Enterococcus faecalis (E. faecalis) was evaluated by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration required to kill 99% bacteria (MBC99) and by conducting dynamic time-killing assays. Metformin 73-82 SAFB like transcription modulator Homo sapiens 84-87 33955025-1 2021 A selective and simple salting out assisted thin layer chromatographic methodology was developed for the simultaneous determination of two oral hypoglycemic drugs; namely dapagliflozin (DAPA) and metformin (MET) in their pure forms, tablets, and spiked human plasma samples. Metformin 196-205 SAFB like transcription modulator Homo sapiens 207-210 33545810-3 2021 In this study, a poly(L-lactic acid) (PLLA)/nanoscale hydroxyapatite (nHA)/metformin (MET) nanocomposite scaffold was constructed via selective laser sintering. Metformin 75-84 SAFB like transcription modulator Homo sapiens 86-89 33545810-5 2021 The PLLA/nHA/MET scaffolds showed improved cell adhesion, appropriate porosity, good biocompatibility and osteogenic-induced ability in vitro because metformin improves water solubility and promotes the osteogenic differentiation of cells within the scaffold. Metformin 150-159 SAFB like transcription modulator Homo sapiens 13-16 33162888-2 2020 Nowadays, metformin (MET) has been discovered to improve endothelial function, but studies regarding the mechanism of MET improving endothelial cell function and alleviating endothelial function under hyperglycemia are still extremely limited. Metformin 10-19 SAFB like transcription modulator Homo sapiens 21-24 32930254-1 2020 The combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. Metformin 48-57 SAFB like transcription modulator Homo sapiens 59-62 33108409-2 2020 Metformin (1,1-dimethylbiguanide hydrochloride, MET), has been shown to decrease tumor cell proliferation, but its effects have yet to be explored with respect to MOs (monocytes) activity during their crosstalk with breast cancer cells. Metformin 0-9 SAFB like transcription modulator Homo sapiens 48-51 32173428-4 2020 Besides, agar/kappa-carrageenan mixed hydrogels were used as carriers for the delivery of metformin hydrochloride (MET). Metformin 90-113 SAFB like transcription modulator Homo sapiens 115-118 32051301-2 2020 Sulfonylureas (SU) and the combination of SU and metformin (SU+MET) were the most common monotherapy and combination therapies used in Thailand tertiary care hospitals. Metformin 49-58 SAFB like transcription modulator Homo sapiens 63-66 31832799-3 2019 This study presents the development and production, by twin-screw melt granulation technology, of a high-dose immediate-release fixed-dose combination (FDC) product of metformin hydrochloride (MET) and sitagliptin phosphate (SIT), with drug loads of 80% w/w and 6% w/w, respectively. Metformin 168-191 SAFB like transcription modulator Homo sapiens 193-196 31633875-4 2019 Furosemide (FUR) and metformin (MET) were added to 99m Tc-DTPA solution (weight ratios 1/1 vol:vol) followed by the quantification of 99m Tc-DTPA binding rates to HSA (40 g/L) using equilibrium dialysis and the qualification of this binding using Molecular Modeling methods. Metformin 21-30 SAFB like transcription modulator Homo sapiens 32-35 29933869-1 2018 Metformin (MET) has possibilities to be utilized as an adjunct of tuberculosis (TB) therapy for controlling the growth of Mycobacterium tuberculosis (M. tuberculosis). Metformin 0-9 SAFB like transcription modulator Homo sapiens 11-14