PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28947430-6	2017	Metformin (200 mg/kg/d) was used to treat wild-type and Sirt2 knockout mice infused with Ang II.	Metformin	0-9	sirtuin 2	Mus musculus	56-61	
28947430-14	2017	Remarkably, the loss of SIRT2 blunted the response of AMPK to metformin treatment in mice infused with Ang II and repressed the metformin-mediated reduction of cardiac hypertrophy and protection of cardiac function.	Metformin	62-71	sirtuin 2	Mus musculus	24-29	
25871950-9	2015	Metformin inhibited SirT2 expression in WBCs significantly (P<0.05) and did not induce any significant changes in other SirT forms and p53, whereas it induced p16(INK4a) mRNA expression in WBCs (P<0.05) at the basal levels.	Metformin	0-9	sirtuin 2	Mus musculus	20-25	
28947430-14	2017	Remarkably, the loss of SIRT2 blunted the response of AMPK to metformin treatment in mice infused with Ang II and repressed the metformin-mediated reduction of cardiac hypertrophy and protection of cardiac function.	Metformin	128-137	sirtuin 2	Mus musculus	24-29	
28947430-16	2017	Loss of SIRT2 reduces AMPK activation, promotes aging-related and Ang II-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.	Metformin	113-122	sirtuin 2	Mus musculus	8-13