PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25576058-5	2015	Metformin (but not rapamycin) reduced glucose and insulin levels and expression of miR-34a and its direct targets Notch, Slug, and Snail.	Metformin	0-9	microRNA 34a	Mus musculus	83-90	
26582729-4	2016	In this study, we investigated the molecular crosstalk between miR-34a, the protein product of SIRT1 (sirtuin1), and the antidiabetic drug, metformin, in hyperglycemia-mediated impaired angiogenesis in mouse microvascular endothelial cells (MMECs).	Metformin	140-149	microRNA 34a	Mus musculus	63-70	
26582729-9	2016	In contrast, overexpression of a miR-34a mimic prevents metformin-mediated protection.	Metformin	56-65	microRNA 34a	Mus musculus	33-40	
26582729-10	2016	These data indicate that miR-34a, via the regulation of sirtuin1 expression, has an anti-angiogenic action in MMECs, which can be modulated by metformin.	Metformin	143-152	microRNA 34a	Mus musculus	25-32	
26582729-11	2016	In summary, miR-34a represents both a target whereby metformin mediates its vasculoprotective actions and also a potential therapeutic target for the prevention/treatment of diabetic vascular disease.	Metformin	53-62	microRNA 34a	Mus musculus	12-19