PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32092034-9	2020	Metformin reduced the expression levels of renal cortical FOXO1 and CREB.	Metformin	0-9	forkhead box O1	Rattus norvegicus	58-63	
30873028-4	2019	Here, we report that metformin represses cardiac apoptosis at least in part through inhibition of Forkhead box O1 (FoxO1) pathway.	Metformin	21-30	forkhead box O1	Rattus norvegicus	98-113	
31647955-0	2020	Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway.	Metformin	0-9	forkhead box O1	Rattus norvegicus	103-108	
31647955-3	2020	We found that metformin effectively alleviated the disorders of glycolipid metabolism, renal function injury in diabetic rats, and relieved oxidative stress, enhanced autophagy and slowed down abnormal cell proliferation in high glucose cultured RMCs through AMPK/SIRT1-FoxO1 pathway, indicating the protective role of metformin against the pathological process of DKD.	Metformin	14-23	forkhead box O1	Rattus norvegicus	270-275	
31821581-0	2020	Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis.	Metformin	0-9	forkhead box O1	Rattus norvegicus	69-74	
31821581-6	2020	Sirt1 inhibitor EX527 and metformin were used to observe whether the protective effect of metformin on DN kidney was achieved through Sirt1/FoxO1 autophagic signaling pathway.	Metformin	90-99	forkhead box O1	Rattus norvegicus	140-145	
31821581-8	2020	Sirt1 inhibitor could block the protective effect of metformin on kidney of diabetic rats, suggesting that metformin could alleviate kidney injury in diabetic rats by inducing Sirt1/FoxO1 autophagy signal axis.	Metformin	53-62	forkhead box O1	Rattus norvegicus	182-187	
31821581-8	2020	Sirt1 inhibitor could block the protective effect of metformin on kidney of diabetic rats, suggesting that metformin could alleviate kidney injury in diabetic rats by inducing Sirt1/FoxO1 autophagy signal axis.	Metformin	107-116	forkhead box O1	Rattus norvegicus	182-187	
31821581-9	2020	So metformin could alleviate renal injury in diabetic rats, which may be achieved by regulating Sirt1/FoxO1 autophagic signaling pathway and inducing renal autophagy.	Metformin	3-12	forkhead box O1	Rattus norvegicus	102-107	
30873028-4	2019	Here, we report that metformin represses cardiac apoptosis at least in part through inhibition of Forkhead box O1 (FoxO1) pathway.	Metformin	21-30	forkhead box O1	Rattus norvegicus	115-120	
30873028-8	2019	FoxO1 silencing by siRNA abolished anti-apoptotic effect of metformin under hypoxic stress in H9C2 cells.	Metformin	60-69	forkhead box O1	Rattus norvegicus	0-5