PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31902918-6	2020	Furthermore, metformin also enhanced autophagic flux, inhibited the phosphorylation of the serine/threonine protein kinase (AKT)/mammalian target of rapamycin (mTOR), mitogen-activated protein kinases (MAPKs) related protein levels and the level of miR-221 in LPS-stimulated RAW264.7 cells.	Metformin	13-22	microRNA 221	Homo sapiens	249-256	
33524789-6	2021	First, many studies showed that metformin could induce autophagy via a number of signaling pathways, including AMPK-related signaling pathways (e.g. AMPK/mTOR, AMPK/CEBPD, MiTF/TFE, AMPK/ULK1, and AMPK/miR-221), Redd1/mTOR, STAT, SIRT, Na+/H+ exchangers, MAPK/ERK, PK2/PKR/AKT/ GSK3beta, and TRIB3.	Metformin	32-41	microRNA 221	Homo sapiens	202-209	
25955843-0	2015	Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.	Metformin	0-9	microRNA 221	Homo sapiens	56-63	
31581911-0	2019	Metformin inhibits angiogenesis of endothelial progenitor cells via miR-221-mediated p27 expression and autophagy.	Metformin	0-9	microRNA 221	Homo sapiens	68-75	
31581911-2	2019	Results: EPC growth and miR-221 expression decreased concentration-dependence with metformin, and a negative correlation was observed between miR-221 expression and metformin concentration (p < 0.001).	Metformin	83-92	microRNA 221	Homo sapiens	24-31	
31581911-2	2019	Results: EPC growth and miR-221 expression decreased concentration-dependence with metformin, and a negative correlation was observed between miR-221 expression and metformin concentration (p < 0.001).	Metformin	165-174	microRNA 221	Homo sapiens	142-149	
31581911-3	2019	miR-221 overexpression using a mimic decreased the metformin-mediated angiogenic effects in EPCs (p < 0.01).	Metformin	51-60	microRNA 221	Homo sapiens	0-7	
31581911-4	2019	Metformin increased p27 and LC3II expression and AMP-activated protein kinase (AMPK) phosphorylation, and decreased p62 expression, while miR-221 overexpression reversed the effects of metformin.	Metformin	185-194	microRNA 221	Homo sapiens	138-145	
25955843-5	2015	We demonstrated that metformin suppressed the expression of miR-221, one of the most well-known oncogenic microRNAs, in human pancreatic cancer PANC-1 cells.	Metformin	21-30	microRNA 221	Homo sapiens	60-67	
25955843-6	2015	Moreover, we showed that the down-regulation of miR-221 by metformin caused G1-phase arrest via the up-regulation of p27, one of the direct targets of miR-221.	Metformin	59-68	microRNA 221	Homo sapiens	48-55	
25955843-6	2015	Moreover, we showed that the down-regulation of miR-221 by metformin caused G1-phase arrest via the up-regulation of p27, one of the direct targets of miR-221.	Metformin	59-68	microRNA 221	Homo sapiens	151-158	
23648338-5	2013	miR-221/222 levels inversely correlated with metformin dose.	Metformin	45-54	microRNA 221	Homo sapiens	0-7