PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22343549-0	2012	Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.	Metformin	42-51	ghrelin and obestatin prepropeptide	Rattus norvegicus	61-68	
23066988-0	2013	Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells.	Metformin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	28-35	
23066988-2	2013	Metformin treatment is also associated with lower circulating levels of the orexigenic hormone ghrelin.	Metformin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	95-102	
23066988-4	2013	Metformin significantly reduced ghrelin secretion and proghrelin mRNA production and both these effects were blocked by co-incubation with the AMPK inhibitor compound C. Furthermore, the AMPK activator 5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) significantly inhibited ghrelin secretion.	Metformin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	32-39	
23066988-4	2013	Metformin significantly reduced ghrelin secretion and proghrelin mRNA production and both these effects were blocked by co-incubation with the AMPK inhibitor compound C. Furthermore, the AMPK activator 5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) significantly inhibited ghrelin secretion.	Metformin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	57-64	
23066988-7	2013	Our results show that Metformin directly inhibits stomach ghrelin production and secretion through AMPK.	Metformin	22-31	ghrelin and obestatin prepropeptide	Rattus norvegicus	58-65	
23066988-8	2013	This reduction in ghrelin secretion may be one of the key components in Metformin"s mechanism of weight loss.	Metformin	72-81	ghrelin and obestatin prepropeptide	Rattus norvegicus	18-25	
22343549-2	2012	The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin.	Metformin	88-97	ghrelin and obestatin prepropeptide	Rattus norvegicus	204-211	
22343549-5	2012	RESULTS: Metformin suppressed the increase in food consumption induced by intracerebroventricular ghrelin in a dose-dependent manner.	Metformin	9-18	ghrelin and obestatin prepropeptide	Rattus norvegicus	98-105	
22343549-8	2012	Metformin treatment blocked ghrelin-induced activation of hypothalamic AMPK/ACC/Raptor and restored mTOR activity without affecting S6K phosphorylation.	Metformin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	28-35	
22343549-10	2012	CONCLUSION: Metformin could reduce food intake by preventing ghrelin-induced AMPK signalling and mTOR inhibition in the hypotalamus.	Metformin	12-21	ghrelin and obestatin prepropeptide	Rattus norvegicus	61-68