PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29286158-0 2018 Metformin inhibits HaCaT cell viability via the miR-21/PTEN/Akt signaling pathway. Metformin 0-9 microRNA 21 Homo sapiens 48-54 33352227-8 2021 Furthermore, we use miR-21 as an example to explain the specific molecular mechanism underlying metformin-mediated regulation of the miRNA signaling pathway controlling angiogenesis and vascular protective effects. Metformin 96-105 microRNA 21 Homo sapiens 20-26 30088260-10 2018 The oncogenic microRNAs miR-21 and miR-155 were found to be downregulated by metformin, which may be correlated with the suppression of cell proliferation and/or migration. Metformin 77-86 microRNA 21 Homo sapiens 24-30 30088260-14 2018 Finally, we found that metformin may modulate the pro-apoptotic Bax, anti-apoptotic Bcl-2, MMP-2, MMP-9, miR-21 and miR-155 expression levels. Metformin 23-32 microRNA 21 Homo sapiens 105-111 34087084-4 2021 However, the effect of metformin administration on hsa-miR-21-5p and MMP9 has not been evaluated in T2DM and DN patients. Metformin 23-32 microRNA 21 Homo sapiens 51-61 34087084-10 2021 However, in metformin-treated group, a downregulation of hsa-miR-21-5p and upregulation of MMP9 was observed. Metformin 12-21 microRNA 21 Homo sapiens 57-67 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 0-9 microRNA 21 Homo sapiens 27-33 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 0-9 microRNA 21 Homo sapiens 421-431 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 0-9 microRNA 21 Homo sapiens 514-524 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 280-289 microRNA 21 Homo sapiens 27-33 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 280-289 microRNA 21 Homo sapiens 137-147 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 280-289 microRNA 21 Homo sapiens 315-325 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 280-289 microRNA 21 Homo sapiens 421-431 34087084-12 2021 Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p. Metformin 280-289 microRNA 21 Homo sapiens 514-524 33059952-11 2021 RESULTS: Data showed that metformin decreased cell survival and expression of miRNA-21, miRNA-155, and miRNA-182 (p <0.05). Metformin 26-35 microRNA 21 Homo sapiens 78-86 29286158-7 2018 Metformin treatment downregulated miR-21 expression (t=-8.903, P<0.05). Metformin 0-9 microRNA 21 Homo sapiens 34-40 29286158-10 2018 Metformin was, therefore, concluded to inhibit HaCaT cell growth in a time-and dose-dependent manner, and the miR-21/PTEN/Akt signaling pathway may serve a crucial role in the molecular mechanism of metformin"s effect on HaCaT cells. Metformin 199-208 microRNA 21 Homo sapiens 110-116 28230206-0 2017 MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway. Metformin 49-58 microRNA 21 Homo sapiens 0-8 28230206-3 2017 However, the precise regulatory mechanisms by which the metformin-induced endothelial suppression and its effects on miR-21-dependent pathways are still unclear. Metformin 56-65 microRNA 21 Homo sapiens 117-123 28230206-4 2017 Bioinformatic analysis and identification of miR-21 and its targets and their effects on metformin-induced antiangiogenic activity were assessed using luciferase assays, quantitative real-time PCR, western blots, scratch assays, CCK-8 assays and tubule formation assays. Metformin 89-98 microRNA 21 Homo sapiens 45-51 28230206-5 2017 In this study, miR-21 was strikingly downregulated by metformin in a time- and dose-dependent manner. Metformin 54-63 microRNA 21 Homo sapiens 15-21 28230206-7 2017 Overexpression of miR-21 abrogated the metformin-mediated inhibition of endothelial cells proliferation, migration, tubule formation and the TGF-beta-induced AKT, SMAD- and ERK-dependent phosphorylations, and conversely, down-regulation of miR-21 aggravated metformin"s action and revealed significant promotion effects. Metformin 39-48 microRNA 21 Homo sapiens 18-24 28230206-7 2017 Overexpression of miR-21 abrogated the metformin-mediated inhibition of endothelial cells proliferation, migration, tubule formation and the TGF-beta-induced AKT, SMAD- and ERK-dependent phosphorylations, and conversely, down-regulation of miR-21 aggravated metformin"s action and revealed significant promotion effects. Metformin 39-48 microRNA 21 Homo sapiens 240-246 28230206-7 2017 Overexpression of miR-21 abrogated the metformin-mediated inhibition of endothelial cells proliferation, migration, tubule formation and the TGF-beta-induced AKT, SMAD- and ERK-dependent phosphorylations, and conversely, down-regulation of miR-21 aggravated metformin"s action and revealed significant promotion effects. Metformin 258-267 microRNA 21 Homo sapiens 18-24 28230206-8 2017 Our study broadens our understanding of the regulatory mechanism of miR-21 mediating metformin-induced anti-angiogenic effects, providing important implications regarding the design of novel miRNA-based therapeutic strategies against angiogenesis. Metformin 85-94 microRNA 21 Homo sapiens 68-74 26496641-0 2016 Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression. Metformin 0-9 microRNA 21 Homo sapiens 71-77 22322462-0 2012 MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. Metformin 115-124 microRNA 21 Homo sapiens 0-11