PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21340016-5	2011	CAT, glutathione reductase (GR), TAS, and GSH remained significantly reduced in the diabetic rats treated with metformin and/or glibenclamide.	Metformin	111-120	glutathione-disulfide reductase	Rattus norvegicus	5-26	
29658305-8	2018	The rise in total antioxidant capacity after melatonin and particularly metformin and melatonin combination might result from the initiation of anaerobic metabolism and increasing SOD, GR, and glutathione peroxidase activity.	Metformin	72-81	glutathione-disulfide reductase	Rattus norvegicus	185-187	
29658305-5	2018	Metformin administration restored succinate dehydrogenase and lactate dehydrogenase activity and associated ROS production and OMP content to the level of intact rats, with predominant activation of superoxide dismutase (SOD) and glutathione reductase (GR).	Metformin	0-9	glutathione-disulfide reductase	Rattus norvegicus	230-251	
29658305-5	2018	Metformin administration restored succinate dehydrogenase and lactate dehydrogenase activity and associated ROS production and OMP content to the level of intact rats, with predominant activation of superoxide dismutase (SOD) and glutathione reductase (GR).	Metformin	0-9	glutathione-disulfide reductase	Rattus norvegicus	253-255	
29151256-6	2018	Metformin caused a decrease in oxidative stress in the heart, accompanied by a decrease in diene conjugates, the elimination of ROS (stable total antioxidant status), and the activation of catalase and glutathione reductase.	Metformin	0-9	glutathione-disulfide reductase	Rattus norvegicus	202-223	
21340016-5	2011	CAT, glutathione reductase (GR), TAS, and GSH remained significantly reduced in the diabetic rats treated with metformin and/or glibenclamide.	Metformin	111-120	glutathione-disulfide reductase	Rattus norvegicus	28-30	
21340016-6	2011	In contrast, metformin or glibenclamide combined with honey significantly increased CAT, GR, TAS, and GSH.	Metformin	13-22	glutathione-disulfide reductase	Rattus norvegicus	89-91	
18673148-8	2008	We observed that metformin, besides its antihyperglycemic action, induces a significant decrease in TBARS and MDA levels, GPx and GRed activities and a significant increase in GSH levels and MnSOD activity.	Metformin	17-26	glutathione-disulfide reductase	Rattus norvegicus	130-134