PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23225247-8	2013	Furthermore, metformin at 0.01 mM completely suppressed the AGEs-induced upregulation of RAGE and VEGF mRNA levels in MCF-7 cells.	Metformin	13-22	long intergenic non-protein coding RNA 914	Homo sapiens	89-93	
23225247-9	2013	An inhibitor of AMP-activated protein kinase, compound C significantly blocked the growth-inhibitory and RAGE and VEGF suppressing effects of metformin in AGEs-exposed MCF-7 cells.	Metformin	142-151	long intergenic non-protein coding RNA 914	Homo sapiens	105-109	
23225247-10	2013	Our present study suggests that metformin could inhibit the AGEs-induced growth and VEGF expression in MCF-7 breast cancer cells by suppressing RAGE gene expression via AMP-activated protein kinase pathway.	Metformin	32-41	long intergenic non-protein coding RNA 914	Homo sapiens	144-148	
23225247-11	2013	Metformin may protect against breast cancer expansion in diabetic patients by blocking the AGEs-RAGE axis.	Metformin	0-9	long intergenic non-protein coding RNA 914	Homo sapiens	96-100	
22100460-0	2012	Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.	Metformin	22-31	long intergenic non-protein coding RNA 914	Homo sapiens	89-93	
22100460-3	2012	Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis is involved in diabetic nephropathy, it is conceivable that metformin and irbesartan additively could protect against the AGEs-RAGE-induced tubular cell injury.	Metformin	164-173	long intergenic non-protein coding RNA 914	Homo sapiens	94-98	
22100460-3	2012	Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis is involved in diabetic nephropathy, it is conceivable that metformin and irbesartan additively could protect against the AGEs-RAGE-induced tubular cell injury.	Metformin	164-173	long intergenic non-protein coding RNA 914	Homo sapiens	231-235	
22100460-6	2012	Compared with AGEs-modified BSA prepared without metformin (AGEs-MF0), those prepared in the presence of 30 mM or 100 mM metformin (AGEs-MF30 or AGEs-MF100) significantly reduced RAGE mRNA level, reactive oxygen species (ROS) generation, apoptosis, monocyte chemoattractant protein-1 and transforming growth factor-beta mRNA level in tubular cells.	Metformin	121-130	long intergenic non-protein coding RNA 914	Homo sapiens	179-183	
22100460-8	2012	Our present study suggests that combination therapy with metformin and irbesartan may have therapeutic potential in diabetic nephropathy; it could play a protective role against tubular injury in diabetes not only by inhibiting AGEs formation, but also by attenuating the deleterious effects of AGEs via down-regulating RAGE expression and subsequently suppressing ROS generation.	Metformin	57-66	long intergenic non-protein coding RNA 914	Homo sapiens	320-324