PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12407167-2 2002 METHODS: Primary cultured hRPE cells were incubated with various concentrations of oltipraz followed by treatment with the chemical oxidant tert-butylhydroperoxide (tBH). tert-Butylhydroperoxide 140-163 ribulose-5-phosphate-3-epimerase Homo sapiens 26-30 12407167-6 2002 RESULTS: Treatment of hRPE cells with oltipraz inhibited tBH-induced cell death in a concentration-dependent manner with significant inhibition at 50 micro M. Olitpraz (50 micro M) increased GSH levels in hRPE cells by approximately 18% and in hRPE mitochondrial fractions by approximately 50% after 24 hours of exposure. tert-Butylhydroperoxide 57-60 ribulose-5-phosphate-3-epimerase Homo sapiens 22-26 12407167-8 2002 CONCLUSIONS: Oltipraz protects hRPE cells against tBH induced injury. tert-Butylhydroperoxide 50-53 ribulose-5-phosphate-3-epimerase Homo sapiens 31-35 26990160-3 2016 Human RPE cells were treated with 150 muM tert-Butyl hydroperoxide (tBH) in the absence/presence of HN (0.5-10 mug/mL) for 24 hours. tert-Butylhydroperoxide 68-71 ribulose-5-phosphate-3-epimerase Homo sapiens 6-9 12147583-12 2002 The nondividing hRPE cells appeared more susceptible to tBH-induced apoptosis. tert-Butylhydroperoxide 56-59 ribulose-5-phosphate-3-epimerase Homo sapiens 16-20 10440245-5 1999 Sensitivity of hRPE cells to oxidative stress was determined using tert-butylhydroperoxide as the oxidative agent. tert-Butylhydroperoxide 67-90 ribulose-5-phosphate-3-epimerase Homo sapiens 15-19 10102293-2 1999 METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time. tert-Butylhydroperoxide 95-115 ribulose-5-phosphate-3-epimerase Homo sapiens 18-22 10102293-2 1999 METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time. tert-Butylhydroperoxide 117-120 ribulose-5-phosphate-3-epimerase Homo sapiens 18-22 10102293-6 1999 RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage. tert-Butylhydroperoxide 9-29 ribulose-5-phosphate-3-epimerase Homo sapiens 89-93 10102293-8 1999 CONCLUSIONS: Results indicate that tBH can induce apoptosis in hRPE, probably by triggering the mitochondrial permeability transition, which results in swelling and release of mitochondrial intermembrane proteins. tert-Butylhydroperoxide 35-38 ribulose-5-phosphate-3-epimerase Homo sapiens 63-67 11581219-7 2001 The expression of RPE-differentiated specific genes, including FGFR2, CRALBP, and RPE65 mRNAs, was downregulated with tBH or H2O2 treatment. tert-Butylhydroperoxide 118-121 ribulose-5-phosphate-3-epimerase Homo sapiens 18-21 23257616-6 2013 RESULTS: hRPE cells exposed to a regimen of TBHP for 5 days upregulate expression of several molecules identified in drusen, including molecular chaperones and pro-angiogenic factors. tert-Butylhydroperoxide 44-48 ribulose-5-phosphate-3-epimerase Homo sapiens 9-13 23257616-14 2013 This adult stem cell-based system using chronic TBHP treatment of hRPE represents a novel in vitro model useful for the study of drusen formation and dry AMD pathophysiology. tert-Butylhydroperoxide 48-52 ribulose-5-phosphate-3-epimerase Homo sapiens 66-70