PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15606011-1	2004	AIM: To explore the possible role of p21, cyclin E and cyclin-dependent kinase 2 (CDK2) in the protection of ginsenoside Rg1 against tert-butylhydroperoxide (t-BHP)-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	133-156	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	121-124	
18375874-3	2008	The present study was aimed to investigate whether ginsenoside Rg1 can delay the premature senescence of WI-38 cells induced by t-BHP and to explore the underlying molecular mechanisms.	tert-Butylhydroperoxide	128-133	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	63-66	
18375874-4	2008	First, Rg1 pretreatment markedly reversed senescent morphological changes in WI-38 cells induced by t-BHP.	tert-Butylhydroperoxide	100-105	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	7-10	
18375874-7	2008	These data indicate that ginsenoside Rg1 has an anti-aging effect on t-BHP-induced premature senescence in WI-38 cells.	tert-Butylhydroperoxide	69-74	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	37-40	
15606011-1	2004	AIM: To explore the possible role of p21, cyclin E and cyclin-dependent kinase 2 (CDK2) in the protection of ginsenoside Rg1 against tert-butylhydroperoxide (t-BHP)-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	158-163	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	121-124	
15606011-4	2004	RESULTS: Pretreatment with Rg1 significantly attenuated t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	56-61	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	27-30	
15606011-5	2004	Simultaneously, compared with cells treated with t-BHP alone, Rg1 pretreatment markedly decreased the level of p21 protein and increased the levels of CDK2 and cyclin E. CONCLUSION: p21, cyclin E and CDK2 may be involved in the process of ginsenoside Rg1 protection against t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	49-54	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	62-65	
15606011-5	2004	Simultaneously, compared with cells treated with t-BHP alone, Rg1 pretreatment markedly decreased the level of p21 protein and increased the levels of CDK2 and cyclin E. CONCLUSION: p21, cyclin E and CDK2 may be involved in the process of ginsenoside Rg1 protection against t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	274-279	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	62-65	
27522666-4	2016	We aimed to investigate the effects of Ginsenoside Rg1 on protecting hUCBDSCs from t-BHP-induced oxidative injury and apoptosis, as well as the possible signaling pathway involved.	tert-Butylhydroperoxide	83-88	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	51-54	
27522666-5	2016	It was shown that the treatment of hUCBDSCs with G-Rg1 markedly restored the t-BHP-induced cell viability loss, promoted the CFU-F formation, and inhibited cell apoptosis.	tert-Butylhydroperoxide	77-82	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	51-54	
27522666-8	2016	All these results suggest that G-Rg1 enhances the survival of t-BHP-induced hUCBDSCs and protects them against apoptosis at least partially through Akt-FoxO3a-Bim signaling pathway.	tert-Butylhydroperoxide	62-67	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	33-36	
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	12-15	
25501220-4	2014	The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16(INK4a)-Rb and p19(Arf)-p53-p21(Cip/Waf1) signaling pathways in HSCs.	tert-Butylhydroperoxide	52-76	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	24-27	
25501220-4	2014	The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16(INK4a)-Rb and p19(Arf)-p53-p21(Cip/Waf1) signaling pathways in HSCs.	tert-Butylhydroperoxide	78-83	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	24-27	
21223818-10	2010	CONCLUSIONS: Rg1 can effectively delay the t-BHP-induced senescence of HSCs.	tert-Butylhydroperoxide	43-48	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	13-16	
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	14-17	
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	120-123