PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31223428-9 2019 Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo. tert-Butylhydroperoxide 172-196 eukaryotic translation initiation factor 2A Rattus norvegicus 91-100