PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35096819-6 2021 Mechanistically, we found that TBHP may induce autophagosome and lysosome fusion interruption and lysosomal dysfunction, while apigenin alleviates these phenomena by promoting the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway. tert-Butylhydroperoxide 31-35 transcription factor EB Rattus norvegicus 205-209 30414849-4 2019 METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot. tert-Butylhydroperoxide 121-145 transcription factor EB Rattus norvegicus 9-13 30414849-7 2019 RESULTS: The nuclear localization of TFEB declined in degenerated rat NP tissue as well as in TBHP treated NP cells. tert-Butylhydroperoxide 94-98 transcription factor EB Rattus norvegicus 37-41 30414849-8 2019 Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition. tert-Butylhydroperoxide 76-80 transcription factor EB Rattus norvegicus 43-47 30414849-8 2019 Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition. tert-Butylhydroperoxide 76-80 transcription factor EB Rattus norvegicus 192-196 30414849-11 2019 TFEB overexpression suppressed TBHP-induced apoptosis and senescence via autophagic flux stimulation in NP cell and alleviates puncture-induced IVDD development in vivo. tert-Butylhydroperoxide 31-35 transcription factor EB Rattus norvegicus 0-4 30414849-4 2019 METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot. tert-Butylhydroperoxide 147-151 transcription factor EB Rattus norvegicus 9-13