PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14732289-3 2004 In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP). tert-Butylhydroperoxide 163-186 heme oxygenase 1 Bos taurus 81-97 14732289-3 2004 In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP). tert-Butylhydroperoxide 163-186 heme oxygenase 1 Bos taurus 99-103 14732289-7 2004 We observed the time- and dose-dependent induction of HO-1 mRNA and protein, which was closely associated with decreased intracellular ROS and necrosis against tBHP. tert-Butylhydroperoxide 160-164 heme oxygenase 1 Bos taurus 54-58 14732289-11 2004 These results suggested that not only ortho-dihydroxyl groups but also aromatic ester and methoxyl ester moieties are necessary for full HO-1 induction and cytoprotection against toxic tBHP-derived ROS. tert-Butylhydroperoxide 185-189 heme oxygenase 1 Bos taurus 137-141 14732289-13 2004 Consequently, the combined action of HO-1 and ferritin may protect cells from toxic tBHP-mediated necrosis. tert-Butylhydroperoxide 84-88 heme oxygenase 1 Bos taurus 37-41