PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24705647-0	2014	Acylated and unacylated ghrelin protect MC3T3-E1 cells against tert-butyl hydroperoxide-induced oxidative injury: pharmacological characterization of ghrelin receptor and possible epigenetic involvement.	tert-Butylhydroperoxide	63-87	ghrelin	Mus musculus	24-31	
24705647-2	2014	This study was undertaken to investigate whether ghrelin, previously reported to stimulate osteoblast proliferation, counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells as well as to characterize the ghrelin receptor (GHS-R) involved in such activity.	tert-Butylhydroperoxide	129-153	ghrelin	Mus musculus	49-56	
24705647-2	2014	This study was undertaken to investigate whether ghrelin, previously reported to stimulate osteoblast proliferation, counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells as well as to characterize the ghrelin receptor (GHS-R) involved in such activity.	tert-Butylhydroperoxide	155-160	ghrelin	Mus musculus	49-56	
24705647-3	2014	Pretreatment with ghrelin (10(-7)-10(-11)M) significantly increased viability and reduced apoptosis of MC3T3-E1 cells cultured with t-BHP (250 muM) for three hours at the low concentration of 10(-9)M as shown by MTT assay and Hoechst-33258 staining.	tert-Butylhydroperoxide	132-137	ghrelin	Mus musculus	18-25	
24705647-4	2014	Furthermore, ghrelin prevented t-BHP-induced osteoblastic dysfunction and changes in the cytoskeleton organization evidenced by the staining of the actin fibers with Phalloidin-FITC by reducing reactive oxygen species generation.	tert-Butylhydroperoxide	31-36	ghrelin	Mus musculus	13-20	
24705647-6	2014	Accordingly, unacylated ghrelin (DAG), not binding GHS-R1a, displays the same protective actions of ghrelin against t-BHP-induced cytotoxicity.	tert-Butylhydroperoxide	116-121	ghrelin	Mus musculus	24-31	
24705647-8	2014	In conclusion, our data demonstrate that ghrelin and DAG promote survival of MC3T3-E1 cell exposed to t-BHP-induced oxidative damage.	tert-Butylhydroperoxide	102-107	ghrelin	Mus musculus	41-48