PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33603950-7 2021 Nrf2 knockdown abolished the antioxidative stress and antiapoptotic effects of ANPODRT in NP cells treated with TBHP. tert-Butylhydroperoxide 112-116 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33891955-7 2021 The expression of nuclear factor erythroid 2-related factor-2 (Nrf2) was activated in RPE cells by t-BHP accompanied with an activation of Erk1/2 signaling. tert-Butylhydroperoxide 99-104 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 30277819-6 2019 We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans. tert-Butylhydroperoxide 99-123 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 32812103-0 2020 Protective effect of coumarin-pi against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via enhanced Nrf2 signaling. tert-Butylhydroperoxide 41-46 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. tert-Butylhydroperoxide 56-60 NFE2 like bZIP transcription factor 2 Homo sapiens 151-155 31221142-0 2019 ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress. tert-Butylhydroperoxide 106-126 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 30897380-12 2019 Furthermore, Z-Lig alleviated oxidative stress and cell injury caused by t-BHP via stimulation of the NRF2/ARE pathway. tert-Butylhydroperoxide 73-78 NFE2 like bZIP transcription factor 2 Homo sapiens 102-106 30277819-8 2019 After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high. tert-Butylhydroperoxide 18-22 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 30277819-8 2019 After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high. tert-Butylhydroperoxide 18-22 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 30277819-6 2019 We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans. tert-Butylhydroperoxide 125-129 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 30956868-1 2019 against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. tert-Butylhydroperoxide 8-13 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 30272282-0 2018 Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway. tert-Butylhydroperoxide 67-91 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 30273691-8 2018 In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes. tert-Butylhydroperoxide 3-27 NFE2 like bZIP transcription factor 2 Homo sapiens 132-175 30273691-8 2018 In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes. tert-Butylhydroperoxide 3-27 NFE2 like bZIP transcription factor 2 Homo sapiens 177-181 30273691-8 2018 In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes. tert-Butylhydroperoxide 29-34 NFE2 like bZIP transcription factor 2 Homo sapiens 132-175 30273691-8 2018 In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes. tert-Butylhydroperoxide 29-34 NFE2 like bZIP transcription factor 2 Homo sapiens 177-181 30956868-4 2019 The treatment with chebulic acid attenuated cell death in t-BHP-induced HepG2 liver cells and increased intracellular glutathione content, upregulated the activity of heme oxygenase-1, and also increased the translocation of Nrf2 into the nucleus and Nrf2 target gene expression in a dose-dependent manner. tert-Butylhydroperoxide 58-63 NFE2 like bZIP transcription factor 2 Homo sapiens 225-229 30956868-6 2019 The overall result is that chebulic acid has cytoprotective effect on t-BHP-induced hepatotoxicity in HepG2 cells through Nrf2-mediated antioxidant enzymes. tert-Butylhydroperoxide 70-75 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 29066411-0 2018 Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. tert-Butylhydroperoxide 52-76 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 29066411-8 2018 Collectively, GA effectively protects against t-BHP-induced hepatotoxicity via inducing ERK/Nrf2-mediated antioxidative signaling pathway. tert-Butylhydroperoxide 46-51 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 29066411-2 2018 We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells. tert-Butylhydroperoxide 157-181 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 29066411-2 2018 We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells. tert-Butylhydroperoxide 183-188 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 29871486-0 2018 Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways. tert-Butylhydroperoxide 42-47 NFE2 like bZIP transcription factor 2 Homo sapiens 121-125 28982598-0 2017 Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation. tert-Butylhydroperoxide 31-36 NFE2 like bZIP transcription factor 2 Homo sapiens 80-84 29804278-8 2018 The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. tert-Butylhydroperoxide 81-86 NFE2 like bZIP transcription factor 2 Homo sapiens 230-234 28982598-5 2017 Furthermore, Mlg exposure significantly lessened t-BHP-induced cytotoxicity and ROS production which were evidently abolished by treatment with AMPK and ERK inhibitors and Nrf2 siRNA. tert-Butylhydroperoxide 49-54 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 28982598-6 2017 Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways. tert-Butylhydroperoxide 57-62 NFE2 like bZIP transcription factor 2 Homo sapiens 135-139 28025122-0 2017 Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways. tert-Butylhydroperoxide 42-47 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 28110191-6 2017 Excitingly, Knockout of Nrf2 almost abolished AA-mediated antioxidant activity and cytoprotection against t-BHP. tert-Butylhydroperoxide 106-111 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 28110191-10 2017 Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK. tert-Butylhydroperoxide 103-108 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 27959441-0 2017 Protective effects of Cambodian medicinal plants on tert-butyl hydroperoxide-induced hepatotoxicity via Nrf2-mediated heme oxygenase-1. tert-Butylhydroperoxide 52-76 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 27959441-9 2017 These results indicated that, of the 64 Cambodian plants, P. weberi and T. crispa exhibited hepatoprotective effects on t-BHP-induced cytotoxicity in HepG2 cells, possibly by the induction of Nrf2-mediated expression of HO-1. tert-Butylhydroperoxide 120-125 NFE2 like bZIP transcription factor 2 Homo sapiens 192-196 27190261-8 2016 These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation. tert-Butylhydroperoxide 68-92 NFE2 like bZIP transcription factor 2 Homo sapiens 193-197 27183873-5 2016 Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death. tert-Butylhydroperoxide 236-240 NFE2 like bZIP transcription factor 2 Homo sapiens 99-103 27190261-8 2016 These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation. tert-Butylhydroperoxide 68-92 NFE2 like bZIP transcription factor 2 Homo sapiens 203-207 27656262-10 2016 Collectively, our current data indicated that apigenin exerted potent antioxidant properties in ARPE-19 cells challenged with t-BHP, which were dependent on activation of Nrf2 signaling. tert-Butylhydroperoxide 126-131 NFE2 like bZIP transcription factor 2 Homo sapiens 171-175 24857917-0 2014 The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. tert-Butylhydroperoxide 48-72 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 26241392-10 2015 The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. tert-Butylhydroperoxide 114-118 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 24186494-7 2014 In cultured MIO-M1 cells, NRF2 inhibition significantly decreased antioxidant gene expression and exacerbated tert-butyl hydroperoxide- and hydrogen peroxide-induced oxidative stress. tert-Butylhydroperoxide 110-134 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 24211276-10 2014 Finally, we showed that Nrf2 deficiency blocked the ability of isorhamnetin to protect cells from injury induced by t-BHP. tert-Butylhydroperoxide 116-121 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 21937211-7 2012 Overexpression of Nrf2 increased GSH content and efficiently protected t-BHP-induced mitochondrial membrane potential loss. tert-Butylhydroperoxide 71-76 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 23266269-0 2013 Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. tert-Butylhydroperoxide 81-105 NFE2 like bZIP transcription factor 2 Homo sapiens 137-141 23266269-6 2013 This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. tert-Butylhydroperoxide 85-90 NFE2 like bZIP transcription factor 2 Homo sapiens 169-173 23922950-9 2013 We screened each target against H2O2, tert-butyl hydroperoxide, and 4-hydroxynonenal and subsequently identified three enzymes-catalase, prostaglandin reductase-1, and peroxiredoxin-6-that are critical for Nrf2-mediated protection in astrocytes. tert-Butylhydroperoxide 38-62 NFE2 like bZIP transcription factor 2 Homo sapiens 206-210 22836768-11 2012 Following tBHP treatment, Nrf2 translocated from cytoplasm to nuclei in normal CECs, whereas Nrf2 nuclear localization was not observed in FECD. tert-Butylhydroperoxide 10-14 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 20100471-9 2010 OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK. tert-Butylhydroperoxide 119-123 NFE2 like bZIP transcription factor 2 Homo sapiens 243-247 20100471-7 2010 OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved. tert-Butylhydroperoxide 47-51 NFE2 like bZIP transcription factor 2 Homo sapiens 221-225 17507167-6 2007 Translocation of Nrf2 into the nucleus was increased by the free-radical donor tert-butylhydroperoxide, but not by glutamate or N-methyl-D-aspartic acid (NMDA). tert-Butylhydroperoxide 79-102 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 19591088-10 2010 These results suggest that sauchinone increases the cellular resistance of HepG2 cells to T-butyl hydroperoxide-induced oxidative injury, presumably through the p38 MAPK pathway-Nrf2/ARE-dependent HO-1 expression. tert-Butylhydroperoxide 90-111 NFE2 like bZIP transcription factor 2 Homo sapiens 178-182 34803685-0 2021 Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival. tert-Butylhydroperoxide 24-28 NFE2 like bZIP transcription factor 2 Homo sapiens 118-122 35367421-0 2022 A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway. tert-Butylhydroperoxide 119-124 NFE2 like bZIP transcription factor 2 Homo sapiens 144-148 34575438-4 2021 In this study, xanthohumol prevented tert-butyl hydroperoxide-induced loss of cell viability in human corneal epithelial (HCE-T) cells in a dose-dependent manner and resulted in a significant increase in expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of phase II endogenous antioxidant enzymes. tert-Butylhydroperoxide 37-61 NFE2 like bZIP transcription factor 2 Homo sapiens 243-286 34575438-4 2021 In this study, xanthohumol prevented tert-butyl hydroperoxide-induced loss of cell viability in human corneal epithelial (HCE-T) cells in a dose-dependent manner and resulted in a significant increase in expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of phase II endogenous antioxidant enzymes. tert-Butylhydroperoxide 37-61 NFE2 like bZIP transcription factor 2 Homo sapiens 288-292 35624896-0 2022 Protective Effect of Alpinia oxyphylla Fruit against tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 Cells via Nrf2 Activation and Free Radical Scavenging and Its Active Molecules. tert-Butylhydroperoxide 53-77 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118