PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24394546-5	2014	t-BHP dose-dependent induction of cell apoptosis and stained liver sections relieved the acute rat liver injury were accompanied by sustained phosphorylation of JNK1/2 and p65.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Homo sapiens	161-167	
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	mitogen-activated protein kinase 8	Homo sapiens	117-120	
24394546-8	2014	This study demonstrated that there was an increase in the cellular levels of ETFA in the t-BHP induction in viability and apoptosis via the activation of JNK1/2 and NFkappaB signaling modules.	tert-Butylhydroperoxide	89-94	mitogen-activated protein kinase 8	Homo sapiens	154-160	
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	mitogen-activated protein kinase 8	Homo sapiens	153-159	
20100471-7	2010	OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved.	tert-Butylhydroperoxide	47-51	mitogen-activated protein kinase 8	Homo sapiens	260-263	
20100471-9	2010	OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK.	tert-Butylhydroperoxide	119-123	mitogen-activated protein kinase 8	Homo sapiens	273-276	
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	28-52	mitogen-activated protein kinase 8	Homo sapiens	150-153	
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	54-58	mitogen-activated protein kinase 8	Homo sapiens	145-148	
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	54-59	mitogen-activated protein kinase 8	Homo sapiens	150-153	
31839625-8	2020	t-BHP increased the phosphorylation of JNK and STAT4, the primary up-stream activators of SP-1, but Dex decreased this.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Homo sapiens	39-42	
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	tert-Butylhydroperoxide	81-86	mitogen-activated protein kinase 8	Homo sapiens	268-271	
26948765-7	2016	Cell apoptosis was increased and molecule expressions of the JNK signalling pathway were activated in the tBHP-injured chondrocytes.	tert-Butylhydroperoxide	106-110	mitogen-activated protein kinase 8	Homo sapiens	61-64	
29926623-11	2016	Recombinant adiponectin protected HUVECs from apoptosis induced by t-BHP, which was correlated with the downregulation of p-JNK and active Caspase 3.	tert-Butylhydroperoxide	67-72	mitogen-activated protein kinase 8	Homo sapiens	124-127	
26948765-8	2016	Na2SeO3 protected against tBHP-induced oxidative stress and apoptosis in cells by increasing cell viability, reducing reactive oxygen species generation, increasing Glutathione peroxidase (GPx) activity and down-regulating the JNK pathway.	tert-Butylhydroperoxide	26-30	mitogen-activated protein kinase 8	Homo sapiens	227-230	
26948765-9	2016	These results demonstrate that apoptosis induced by tBHP in chondrocytes might be mediated via up-regulation of the JNK pathway; Na2SeO3 has an effect of anti-apoptosis by down-regulating the JNK signalling pathway.	tert-Butylhydroperoxide	52-56	mitogen-activated protein kinase 8	Homo sapiens	116-119