PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24662601-4	2014	Treatment of tBHP resulted in apoptotic cell death as assessed by TUNEL assay and the expression of apoptosis regulator proteins, Bcl-2 family, caspases and cytochrome c.	tert-Butylhydroperoxide	13-17	BCL2 apoptosis regulator	Homo sapiens	130-135	
27030608-0	2016	Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling.	tert-Butylhydroperoxide	31-36	BCL2 apoptosis regulator	Homo sapiens	68-73	
27030608-8	2016	Exendin-4 downregulated caspase-3 activity and increased Bcl-2 protein levels in t-BHP-treated HUVECs.	tert-Butylhydroperoxide	81-86	BCL2 apoptosis regulator	Homo sapiens	57-62	
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	BCL2 apoptosis regulator	Homo sapiens	194-199	
9465036-3	1998	Although Bcl-2 had no effect on the respiration rate of isolated mitochondria, it prevented both Deltapsi loss and the permeability transition (PT) induced by various reagents, including Ca2+, H2O2, and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	203-227	BCL2 apoptosis regulator	Homo sapiens	9-14	
23984931-5	2013	After tBHP treatment, Bcl-2 protein expression decreased and Bax protein expression increased.	tert-Butylhydroperoxide	6-10	BCL2 apoptosis regulator	Homo sapiens	22-27	
23984931-8	2013	Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs.	tert-Butylhydroperoxide	63-67	BCL2 apoptosis regulator	Homo sapiens	103-108	
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	BCL2 apoptosis regulator	Homo sapiens	212-217	
22980779-4	2012	The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation.	tert-Butylhydroperoxide	69-74	BCL2 apoptosis regulator	Homo sapiens	277-282	
18552516-13	2008	The mechanism of hyperoside protecting against ECV-304 cell apoptosis by TBHP is related with resuming mitochondrial function and regulating the expression of SIRT1 and Bcl-2 family members.	tert-Butylhydroperoxide	73-77	BCL2 apoptosis regulator	Homo sapiens	169-174	
9465036-8	1998	Furthermore, Bcl-2 enhanced H+ efflux but not K+ flux after treatment of mitochondria with Ca2+ or tert-butyl hydroperoxide.	tert-Butylhydroperoxide	99-123	BCL2 apoptosis regulator	Homo sapiens	13-18