PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158	
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	BCL2 associated X, apoptosis regulator	Homo sapiens	200-203	
23984931-5	2013	After tBHP treatment, Bcl-2 protein expression decreased and Bax protein expression increased.	tert-Butylhydroperoxide	6-10	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64	
23984931-8	2013	Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs.	tert-Butylhydroperoxide	63-67	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112	
22980779-4	2012	The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation.	tert-Butylhydroperoxide	69-74	BCL2 associated X, apoptosis regulator	Homo sapiens	283-286	
20119745-5	2010	In addition, the two mentioned compounds inhibit intracellular signalling mechanisms leading to apoptotic cell death, namely those mediated by mitochondria, which was confirmed by their ability to overcome t-BHP-induced morphological changes in the mitochondrial network, loss of mitochondrial membrane potential, increased expression of the pro-apoptotic proteins p53, Bax and AIF and activation of caspases-3 and -9.	tert-Butylhydroperoxide	206-211	BCL2 associated X, apoptosis regulator	Homo sapiens	370-373	
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	BCL2 associated X, apoptosis regulator	Homo sapiens	208-211