PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18666426-7 2008 It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts. tert-Butylhydroperoxide 53-58 insulin like growth factor 1 receptor Homo sapiens 90-104 18666426-9 2008 These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant. tert-Butylhydroperoxide 107-112 insulin like growth factor 1 receptor Homo sapiens 181-195