PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7814299-2 1994 To elucidate the electrophysiological mechanisms underlying these arrhythmias, the effects of tert butyl hydroperoxide (TBH) on the Na+ current (INa) in isolated feline ventricular myocytes were studied using whole-cell patch clamp techniques under 100% O2 bubbling. tert-Butylhydroperoxide 94-118 internexin neuronal intermediate filament protein alpha Homo sapiens 145-148 7814299-2 1994 To elucidate the electrophysiological mechanisms underlying these arrhythmias, the effects of tert butyl hydroperoxide (TBH) on the Na+ current (INa) in isolated feline ventricular myocytes were studied using whole-cell patch clamp techniques under 100% O2 bubbling. tert-Butylhydroperoxide 120-123 internexin neuronal intermediate filament protein alpha Homo sapiens 145-148 7814299-4 1994 Twenty millimoles TBH shifted the steady-state inactivation curve for INa from -77.4 +/- 1.7 to -81.3 +/- 1.8 mV when measured at INa half inhibition voltage (P < 0.01, n = 7), but did not affect the slope factor. tert-Butylhydroperoxide 18-21 internexin neuronal intermediate filament protein alpha Homo sapiens 70-73 7814299-4 1994 Twenty millimoles TBH shifted the steady-state inactivation curve for INa from -77.4 +/- 1.7 to -81.3 +/- 1.8 mV when measured at INa half inhibition voltage (P < 0.01, n = 7), but did not affect the slope factor. tert-Butylhydroperoxide 18-21 internexin neuronal intermediate filament protein alpha Homo sapiens 130-133 7814299-6 1994 These findings suggest that lipid peroxidation in the membrane by TBH reduces INa conductance and voltage-dependent INa availability, most likely as a result of structural damage to the Na+ channels. tert-Butylhydroperoxide 66-69 internexin neuronal intermediate filament protein alpha Homo sapiens 78-81 7814299-6 1994 These findings suggest that lipid peroxidation in the membrane by TBH reduces INa conductance and voltage-dependent INa availability, most likely as a result of structural damage to the Na+ channels. tert-Butylhydroperoxide 66-69 internexin neuronal intermediate filament protein alpha Homo sapiens 116-119