PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19277051-6	2009	Heme-HPX complexes induce HO1 and, consequently, protect primary neurons against the toxicity of both heme and pro-oxidant tert-butyl hydroperoxide; such protection was decreased in HO1(-/-) neuronal cultures.	tert-Butylhydroperoxide	123-147	heme oxygenase 1	Mus musculus	182-185	
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	heme oxygenase 1	Mus musculus	209-213	
33027770-4	2020	SAC increased the nuclear translocation of Nrf2 and activated the Nrf2/HO1 signaling pathway in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	96-100	heme oxygenase 1	Mus musculus	71-74	
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	heme oxygenase 1	Mus musculus	112-128	
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	heme oxygenase 1	Mus musculus	130-134	
33027770-7	2020	Collectively, these findings show that SAC ameliorates OA pathology in TBHP-treated chondrocytes and DMM model mice by activating the Nrf2/HO1 signaling pathway.	tert-Butylhydroperoxide	71-75	heme oxygenase 1	Mus musculus	139-142	
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	10-34	heme oxygenase 1	Mus musculus	175-179	
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	36-41	heme oxygenase 1	Mus musculus	175-179	
26576227-6	2015	Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors.	tert-Butylhydroperoxide	50-55	heme oxygenase 1	Mus musculus	137-141	
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	heme oxygenase 1	Mus musculus	96-100	
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	58-82	heme oxygenase 1	Mus musculus	52-56	
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	58-82	heme oxygenase 1	Mus musculus	248-252	
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	84-89	heme oxygenase 1	Mus musculus	52-56	
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	84-89	heme oxygenase 1	Mus musculus	248-252