PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8662659-10 1996 Clones expressing elevated human (386-5938 milliunits/mg) or rat (4-597 milliunits/mg, benzaldehyde/NADP+ substrate) ALDH-3 activity were 1.3- to 12-fold resistant to mafosfamide relative to control cells (<1 milliunit/mg). benzaldehyde 87-99 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 117-123 11306044-4 2001 Finally, our quantum mechanical model of benzaldehyde in the active site of ALDH demonstrates that the enzyme requires only minor conformational changes to be poised for nucleophilic attack on the substrate. benzaldehyde 41-53 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 76-80 9292276-7 1997 Particularly, BA was highly toxic to the HTC cells, which possessed the highest ALDH levels. benzaldehyde 14-16 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 80-84 9292276-8 1997 Moreover, the treatment with (diethylamino)benzaldehyde, an ALDH inhibitor, completely abolished the toxicity of BA. benzaldehyde 113-115 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 60-64 8083225-5 1994 Pretreatment of the highest activity cell line (3A1-31A) with 75 microM diethylaminobenzaldehyde, an ALDH substrate and inhibitor of benzaldehyde oxidation, effectively reversed the 3.8-fold resistance in this line; drug sensitivity was unaffected by diethylaminobenzaldehyde in the control transfected cell line. benzaldehyde 84-96 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 101-105 2400809-6 1990 Levels of aldehyde dehydrogenase (ALDH), which inactivates CY by prevention of formation of PhM, were significantly elevated in these CY-resistant AML cells: cytosolic and particulate ALDH fractions from these cells were 11 to 13 times control with NAD cofactor and propanal substrate and three to four times control with NADP cofactor and benzaldehyde substrate. benzaldehyde 340-352 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 10-32 2060039-3 1991 The cytosolic ALDH activity of the liver was determined either with propionaldehyde and NAD (P/NAD), or with benzaldehyde and NADP (B/NADP). benzaldehyde 109-121 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 14-18 2400809-6 1990 Levels of aldehyde dehydrogenase (ALDH), which inactivates CY by prevention of formation of PhM, were significantly elevated in these CY-resistant AML cells: cytosolic and particulate ALDH fractions from these cells were 11 to 13 times control with NAD cofactor and propanal substrate and three to four times control with NADP cofactor and benzaldehyde substrate. benzaldehyde 340-352 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 34-38 3343508-9 1988 AlDH in upper GI tissues and in liver nodules shared three characteristics: a sharp localization; a preference for Bz and NADP compared to the aliphatic substrate acetaldehyde and NAD; and a high co-enzyme-independent activity in the presence of Bz. benzaldehyde 115-117 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 0-4 2765201-5 1989 Alcohol-resistant AT rats had higher ALDH activity, with benzaldehyde, in most CNS structures than did the alcohol-sensitive ANT"s, significantly so in the lamina II of the somatosensory cortex and the neurons of the lateral hypothalamic area. benzaldehyde 57-69 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 37-41 2805229-3 1989 The ALDH phenotype was determined at intervals over 42 weeks by histochemical analysis, total ALDH activity assays and gel electrophoresis using propionaldehyde and NAD (P-NAD) which characterizes class 1 and 2 ALDH, or benzaldehyde and NADP (B-NADP) to determine class 3 ALDH. benzaldehyde 220-232 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 4-8 2755909-8 1989 An increase of the activity was also noticed when ALDH was measured with NADP and benzaldehyde (B/NADP). benzaldehyde 82-94 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 50-54 3343508-9 1988 AlDH in upper GI tissues and in liver nodules shared three characteristics: a sharp localization; a preference for Bz and NADP compared to the aliphatic substrate acetaldehyde and NAD; and a high co-enzyme-independent activity in the presence of Bz. benzaldehyde 246-248 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 0-4 3008991-2 1986 Like the tumor-associated aldehyde dehydrogenase, bladder NADP+-ALDH is cytosolic and preferentially oxidizes benzaldehyde-like aromatic aldehydes. benzaldehyde 110-122 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 26-48 3811968-4 1986 The activity of ALDH is not only preserved, but also significantly enhanced, when propionaldehyde, phenylacetaldehyde, benzaldehyde and D-glucuronolactone are used as substrates and NAD as the coenzyme. benzaldehyde 119-131 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 16-20 3811968-5 1986 A relative increase of activity is also noted when ALDH is measured with benzaldehyde and NADP. benzaldehyde 73-85 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 51-55 3008991-2 1986 Like the tumor-associated aldehyde dehydrogenase, bladder NADP+-ALDH is cytosolic and preferentially oxidizes benzaldehyde-like aromatic aldehydes. benzaldehyde 110-122 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 64-68 3003181-2 1986 Objectives of this study were first, to determine if liver cancers in vinyl chloride-treated rats also expressed this AlDH phenotype, and second, to quantitate the NAD- and NADP-dependent AlDH activity for the substrates Bz and acetaldehyde (Ac) in the cancers and surrounding tissue. benzaldehyde 221-223 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 118-122 3003181-1 1986 Hepatocarcinogenesis in rats treated with several chemicals is associated with changes in aldehyde dehydrogenase (AlDH) activity, particularly heterogeneous expression of a "tumor specific" phenotype that is very active with aromatic aldehydes, e.g., benzaldehyde (Bz). benzaldehyde 251-263 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 90-112 3003181-1 1986 Hepatocarcinogenesis in rats treated with several chemicals is associated with changes in aldehyde dehydrogenase (AlDH) activity, particularly heterogeneous expression of a "tumor specific" phenotype that is very active with aromatic aldehydes, e.g., benzaldehyde (Bz). benzaldehyde 251-263 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 114-118 3003181-1 1986 Hepatocarcinogenesis in rats treated with several chemicals is associated with changes in aldehyde dehydrogenase (AlDH) activity, particularly heterogeneous expression of a "tumor specific" phenotype that is very active with aromatic aldehydes, e.g., benzaldehyde (Bz). benzaldehyde 265-267 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 90-112 3003181-1 1986 Hepatocarcinogenesis in rats treated with several chemicals is associated with changes in aldehyde dehydrogenase (AlDH) activity, particularly heterogeneous expression of a "tumor specific" phenotype that is very active with aromatic aldehydes, e.g., benzaldehyde (Bz). benzaldehyde 265-267 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 114-118 3003181-2 1986 Objectives of this study were first, to determine if liver cancers in vinyl chloride-treated rats also expressed this AlDH phenotype, and second, to quantitate the NAD- and NADP-dependent AlDH activity for the substrates Bz and acetaldehyde (Ac) in the cancers and surrounding tissue. benzaldehyde 221-223 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 188-192 3994763-4 1985 When the Km values for benzaldehyde with aldehyde dehydrogenase (ALDH) were determined, two Km values (3 and 120 microM) were obtained with mitochondria, but only a single Km value (25 microM) was obtained with the cytosolic fraction. benzaldehyde 23-35 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 41-63 3994763-4 1985 When the Km values for benzaldehyde with aldehyde dehydrogenase (ALDH) were determined, two Km values (3 and 120 microM) were obtained with mitochondria, but only a single Km value (25 microM) was obtained with the cytosolic fraction. benzaldehyde 23-35 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 65-69 3994763-6 1985 In intact mitochondria, with 200 microM acetaldehyde or benzaldehyde the matrix space enzyme accounted for 77 and 62%, respectively, of the total ALDH activity. benzaldehyde 56-68 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 146-150 3994763-13 1985 It can be concluded that, in rat, disulfiram inhibiting liver ALDH not only affects oxidation of acetaldehyde, but also that of benzaldehyde. benzaldehyde 128-140 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 62-66 6488182-4 1984 HTC, JM1, and JM2 express the tumor ALDH phenotype, as indicated by elevated NADP-dependent, benzaldehyde-oxidizing activity, the appearance of new isozymes by electrophoresis, and characteristic histochemical localization of ALDH activity in situ. benzaldehyde 93-105 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 36-40 4015840-3 1985 One isozyme, designated ALDH3, which is very active against benzaldehyde, was found to show variable expression in hybrids made between rat hepatoma cells and human fibroblasts or fetal liver. benzaldehyde 60-72 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 24-29 6149820-2 1984 The hepatic ALDH phenotype was determined at intervals over 280 days by histochemical analysis, total ALDH activity assays and gel electrophoresis, using propionaldehyde and NAD (P/NAD) to characterize normal liver ALDH activity or benzaldehyde and NADP (B/NADP) to determine tumor-associated ALDH activity. benzaldehyde 232-244 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 12-16 6196110-5 1983 During hepatocarcinogenesis, ALDH staining patterns in grossly normal liver range from normal-appearing to patterns of distinct, intense focal hepatocyte staining with propionaldehyde-NAD and/or benzaldehyde-NADP. benzaldehyde 195-207 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 29-33 6196110-8 1983 Neoplasms with elevated ALDH activity with propionaldehyde-NAD and/or benzaldehyde-NADP, as well as with no detectable ALDH, have been observed. benzaldehyde 70-82 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 24-28